Press Release

Exelixis Announces October 27 Webcast of Its Third Quarter 2008 Financial Results and Business Update Conference Call

October 17, 2008

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--

Exelixis, Inc. (Nasdaq:EXEL) will release its third quarter 2008 financial results on Monday, October 27, 2008, after the markets close. The announcement will be followed by a live webcast at 2:00 p.m. PT/5:00 p.m. ET, in which Exelixis management will discuss the third quarter financial results and give a general update on the company's financial position and business, including its development pipeline and corporate strategy. The webcast may be accessed in the Event Calendar page under Investors at www.exelixis.com.

An archive of this webcast will be available until November 27, 2008. Access numbers for this replay are 1-888-286-8010 (domestic) and 1-617-801-6888 (international); the replay passcode number is 92881861.

About Exelixis

Exelixis, Inc. is a development-stage biotechnology company dedicated to the discovery and development of novel small molecule therapeutics for the treatment of cancer and other serious diseases. The company is leveraging its fully integrated drug discovery platform to fuel the growth of its development pipeline, which is primarily focused on cancer. Currently, Exelixis' broad product pipeline includes investigational compounds in phase 3, phase 2, and phase 1 clinical development. Exelixis has established strategic corporate alliances with major pharmaceutical and biotechnology companies, including GlaxoSmithKline, Bristol-Myers Squibb, Genentech, Wyeth Pharmaceuticals, and Daiichi-Sankyo. For more information, please visit the company's web site at www.exelixis.com.

Exelixis and the Exelixis logo are registered U.S. trademarks.

Source: Exelixis, Inc.