☐ | Preliminary Proxy Statement |
☐ | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) |
☒ | Definitive Proxy Statement |
☐ | Definitive Additional Materials |
☐ | Soliciting Material under §240.14a-12 |
☒ | No fee required. |
☐ | Fee paid previously with preliminary materials. |
☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11. |
Stelios Papadopoulos, Ph.D. Chair of the Board | Julie Anne Smith Chair of the Compensation Committee |
Important notice regarding the availability of proxy materials for the 2024 Annual Meeting of Stockholders to be held on May 30, 2024, at 9:00 a.m., Pacific Time, via live webcast at www.virtualshareholdermeeting.com/ EXEL2024. You will need your 16-digit control number provided on your Notice of Internet Availability of Proxy Materials, your proxy card or your voting instruction form to gain access to the virtual Annual Meeting. The Proxy Statement and Annual Report to stockholders are available at www.exel- annualstockholdermeeting.com. The Board of Directors recommends that you vote “FOR” Proposal Nos. 1-4 identified above. |
1.To elect the eleven nominees for director named in the Proxy Statement accompanying this Notice of Annual Meeting to hold office until the next annual meeting of stockholders and until his or her successor is duly elected and qualified or until his or her death, resignation or removal. |
2.To ratify the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as Exelixis’ independent registered public accounting firm for the fiscal year ending January 3, 2025. |
3.To amend and restate the Exelixis, Inc. 2000 Employee Stock Purchase Plan to, among other things, increase the number of shares authorized for issuance by 6,000,000 shares. |
4.To approve, on an advisory basis, the compensation of Exelixis’ Named Executive Officers, as disclosed in the Proxy Statement accompanying this Notice of Annual Meeting. |
5.To conduct any other business properly brought before the meeting. |
Important notice regarding the availability of proxy materials for the 2024 Annual Meeting of Stockholders to be held on May 30, 2024, at 9:00 a.m., Pacific Time, via live webcast at www.virtualshareholdermeeting.com/ EXEL2024. You will need your 16-digit control number provided on your Notice of Internet Availability of Proxy Materials, your proxy card or your voting instruction form to gain access to the virtual Annual Meeting. The Proxy Statement and Annual Report to stockholders are available at www.exel- annualstockholdermeeting.com. |
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i | Exelixis, Inc. |
Proxy Statement | Questions and Answers |
2024 Proxy Statement | 1 |
2 | Exelixis, Inc. |
At Virtual Meeting | ›› To vote at the Annual Meeting, follow the instructions at www.virtualshareholdermeeting.com/ EXEL2024. You will need your 16-digit control number provided on your Notice of Availability, your proxy card or your voting instruction form to gain access to the Annual Meeting. |
Via Internet | ›› To vote on the Internet, go to www.proxyvote.com and follow the instructions provided in the Notice of Availability. You will need your 16-digit control number provided on your Notice of Availability, your proxy card or your voting instruction form to vote your shares in advance of the meeting. Your vote must be received by 11:59 p.m., Eastern Time, on May 29, 2024, to be counted. |
By Telephone | ›› To vote by telephone, follow the instructions and call the number provided in the proxy materials to transmit your voting instructions. Your vote must be received by 11:59 p.m. Eastern Time, on May 29, 2024, to be counted. |
By Mail | ›› To vote by mail, follow the instructions provided in the proxy materials, request a paper copy of the proxy materials and then complete, sign and date the proxy card enclosed with the paper copy of the proxy materials and return it promptly in the envelope that will be provided. If you return your signed proxy card to us before the Annual Meeting, we will vote your shares as you direct. |
Proxy Statement | Questions and Answers |
2024 Proxy Statement | 3 |
We provide Internet proxy voting to allow you to vote your shares online, with procedures designed to ensure the authenticity and correctness of your proxy vote instructions. However, please be aware that you must bear any costs associated with your Internet access, such as usage charges from Internet access providers and telephone companies. |
4 | Exelixis, Inc. |
Proxy Statement | Questions and Answers |
2024 Proxy Statement | 5 |
6 | Exelixis, Inc. |
Proxy Statement | Questions and Answers |
2024 Proxy Statement | 7 |
8 | Exelixis, Inc. |
Proposal Snapshot – Item 1. Election of Directors What is being voted on: Election of 11 director nominees to our Board. Board recommendation: After a review of the individual qualifications and experience of each of our director nominees and his or her contributions to our Board (as applicable), our Board determined unanimously to recommend that shareholders vote FOR all of our director nominees. |
Proposal 1 | Election of Directors |
2024 Proxy Statement | 9 |
Director Nominees | Age | Position | Director Since |
Mary C. Beckerle, Ph.D. | 69 | Independent Director | 2024 |
S. Gail Eckhardt, M.D. | 66 | Independent Director | 2024 |
Maria C. Freire, Ph.D. | 69 | Independent Director | 2018 |
Tomas J. Heyman | 68 | Independent Director | 2023 |
David E. Johnson | 41 | Independent Director | 2023 |
Michael M. Morrissey, Ph.D. | 63 | President and Chief Executive Officer | 2010 |
Robert L. Oliver, Jr. | 65 | Independent Director | 2023 |
Stelios Papadopoulos, Ph.D. | 75 | Independent Chair of the Board | 1994 |
George Poste, DVM, Ph.D., FRS | 79 | Independent Director | 2004 |
Julie Anne Smith | 53 | Independent Director | 2016 |
Jack L. Wyszomierski | 68 | Independent Director | 2004 |
10 | Exelixis, Inc. |
Proposal 1 | Election of Directors |
2024 Proxy Statement | 11 |
10 of 11 Director Nominees are Independent Our Board determined that each of our director nominees (other than Dr. Morrissey) is “independent” within the meaning of applicable SEC rules and regulations and the Nasdaq listing standards. Dr. Garber and Ms. Wright, who are not standing for re-election at our 2024 Annual Meeting, and Drs. Marchesi and Willsey and Mr. Feldbaum, each of whom served as directors for part of 2023 before their respective departures from the Board, were also determined to be independent. In addition, the Board determined that: (i) all directors who serve on the Audit, Compensation and Governance Committees are independent under applicable Nasdaq listing standards; and (ii) all members of the Audit Committee meet the independence requirements under the Exchange Act. |
12 | Exelixis, Inc. |
Director Nominees | ||
Mary C. Beckerle, Ph.D. Chief Executive Officer, Huntsman Cancer Institute at the University of Utah | Director since 2024 Age 69 Key Qualifications and Expertise: Our Board concluded that Dr. Beckerle should continue to serve as a director of Exelixis due to her training as a scientist, her extensive knowledge and experience in the field of cancer research and treatment, and her broad leadership experience, in particular her corporate governance experience, resulting from managing a world-class healthcare organization and service on various public company boards and scientific or advisory boards. Committee Assignments: •Governance Committee •Research & Development Committee Other Current Public Company Boards: •Huntsman Corporation, serving on the Nominating and Corporate Governance Committee and Sustainability Committee •Johnson & Johnson, serving on the Regulatory Compliance & Sustainability Committee and Science & Technology Committee (Chair) | |
Mary C. Beckerle, Ph.D., has been a director since January 2024. Since 2006, Dr. Beckerle has served as Chief Executive Officer of the Huntsman Cancer Institute at the University of Utah, and is also currently serving as Associate Vice President for Cancer Affairs and a Distinguished Professor of Biology and Oncological Sciences at the University of Utah. She first joined the faculty of the University of Utah in 1986, serving in numerous research and leadership positions over the years, and currently holds the Jon M. Huntsman Presidential Endowed Chair. Dr. Beckerle has served as a member of the board of directors of Huntsman Corporation, a publicly held global manufacturer of specialty chemicals, since 2011, and as a member of the board of directors of Johnson & Johnson, a publicly held diversified healthcare company, since 2015. She has been named a National Association of Corporate Directors (NACD) Corporate Governance Fellow and was a 2018 NACD Directorship 100 Honoree. In addition, she currently serves on a number of scientific and other advisory boards, including the Medical Advisory Board of the Howard Hughes Medical Institute since 2015, as well as on various external advisory boards of National Cancer Institute- designated cancer centers. Previously, Dr. Beckerle served as a member of the Board of Scientific Advisors of the National Cancer Institute from 2018 to 2022, the External Advisory Board of the Dana-Farber/Harvard Cancer Center from 2013 to 2022, the Board of Directors of the American Association for Cancer Research from 2013 to 2016, the American Cancer Society Council for Extramural Grants from 2008 to 2012 (serving as Chair from 2010 to 2012) and the National Institute of Health’s Advisory Committee to the Director from 2007 to 2010, as well as President of the American Society for Cell Biology from 2006 to 2007. She is also an elected member of the National Academy of Sciences, the American Philosophical Society and the American Academy of Arts and Sciences. Dr. Beckerle holds a B.A. in Biology and Psychology (magna cum laude) from Wells College and a Ph.D. in Molecular, Cellular and Developmental Biology from the University of Colorado, Boulder. She completed her post-doctoral fellowship in Anatomy and Cell Biology at the University of North Carolina at Chapel Hill. | ||
Proposal 1 | Director Nominees |
2024 Proxy Statement | 13 |
S. Gail Eckhardt, M.D. Professor and Associate Dean of Experimental Therapeutics, Associate Director of Translational Research, Dan L. Duncan Comprehensive Cancer Center, at Baylor College of Medicine | Director since 2024 Age 66 Key Qualifications and Expertise: Our Board concluded that Dr. Eckhardt should continue to serve as a director of Exelixis due to her skills as a physician and medical researcher, and her leadership experience in drug development and translational medicine relative to oncology, as well as her service on various public company boards and scientific or advisory boards. Committee Assignments: •Compensation Committee •Research & Development Committee Other Current Public Company Boards: •Syros Pharmaceuticals, Inc., serving on the Compensation Committee and the Nominating and Corporate Governance Committee | |
S. Gail Eckhardt, M.D., has been a director since January 2024. Since September 2023, Dr. Eckhardt has served as Professor and Associate Dean of Experimental Therapeutics at Baylor College of Medicine, as well as Associate Director of Translational Research at the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine. Between 2017 and 2023, she was a tenured professor at Dell Medical School at the University of Texas at Austin, where she also served as Chair of the Department of Oncology, Associate Dean of Cancer Programs and as the inaugural Director of the Livestrong Cancer Institutes. Prior to joining the University of Texas, Dr. Eckhardt was a member of the faculty at the University of Colorado School of Medicine from 1999 to 2017 (receiving tenure in 2001), where she had numerous roles and responsibilities, including Division Head of Medical Oncology, Associate Director for Translational Research at the University of Colorado Comprehensive Cancer Center and Director of the Phase I Program and Fellowship. Dr. Eckhardt has served as a member of the board of directors of Syros Pharmaceuticals, Inc., a publicly held biopharmaceutical company focused on developing frontline treatments for patients with hematologic malignancies, since September 2020. In addition, she has served on numerous committees and study sections, including the American Society of Clinical Oncology’s Molecular Oncology Task Force and Board of Directors, the U.S. Food and Drug Administrations’ Oncology Drugs Advisory Committee and the National Cancer Institute’s Cancer Centers Study Section and Investigational Drug Steering Committee, as well as eleven external advisory boards of National Cancer Institute-designated cancer centers. Dr. Eckhardt is also a current member of the National Academies Cancer Policy Forum and was previously a lead mentor in the American Society of Clinical Oncology’s Leadership Development Program and a member of the board of directors of the Association of American Cancer Institutes. Dr. Eckhardt holds a B.S. in Chemistry from Stephen F. Austin State University and an M.D. from the University of Texas Medical Branch in Galveston. She conducted her internship and residency in Internal Medicine at the University of Virginia Medical School, followed by a post-doctoral research fellowship in Experimental and Molecular Medicine at Scripps Research Institute in La Jolla, California and a fellowship in Medical Oncology at the University of California, San Diego. | ||
Maria C. Freire, Ph.D. Former President and Executive Director, Foundation for the National Institutes of Health | Director since 2018 Age 69 Key Qualifications and Expertise: Our Board concluded that Dr. Freire should continue to serve as a director of Exelixis due to her training as a scientist, her knowledge and experience with respect to U.S. and global public health, the biopharmaceutical industry and government healthcare policymaking, as well as her leadership experience in the public sector. Committee Assignments: •Governance Committee (Chair Elect) •Research & Development Committee Other Current Public Company Boards: •Alexandria Real Estate Equities, serving on the Nominating & Corporate Governance Committee and the Science & Technology Committee (Chair) •Biogen Inc., serving on the Compensation and Management Development Committee | |
Maria C. Freire, Ph.D., has been a director since April 2018. From 2012 to 2021, Dr. Freire served as President and Executive Director and as a member of the board of directors of the Foundation for the National Institutes of Health. Previously, she served as President and as a member of the board of directors of the Albert and Mary Lasker Foundation from 2008 to 2012, as President and Chief Executive Officer of the Global Alliance for TB Drug Development from 2011 to 2008 and as Director of the Office of Technology Transfer at the National Institutes of Health from 1995 to 2001. Dr. Freire has served on the board of directors of Biogen Inc., a publicly held biopharmaceutical company focused on the treatment of serious diseases, since 2021, on the board of directors of Alexandria Real Estate Equities, Inc., a publicly held urban office real estate investment trust uniquely focused on collaborative life science and technology campuses, since 2012, and on the board of directors of Koneksa Health, a private digital biomarker company, since 2022. She has previously served on the boards of numerous national and international organizations, including the Science Board of the U.S. Food and Drug Administration, the World Health Organization Commission on Intellectual Property Rights, Innovation and Public Health and the United Nations Secretary General’s High Level Panel on Access to Medicines. Dr. Freire is also a member of the National Academy of Medicine and the Council on Foreign Relations, and she is the recipient of numerous awards, including a 2017 Gold Stevie Award for “Woman of the Year,” the U.S. Department of Health and Human Services Secretary’s Award for Distinguished Service, the Arthur S. Fleming Award and the Bayh-Dole Award. Dr. Freire holds a Ph.D. in Biophysics from the University of Virginia and a B.S. from the Universidad Peruana Cayetano Heredia in Lima, Peru. | ||
14 | Exelixis, Inc. |
Tomas J. Heyman Consultant and Interim Chief Executive Officer, Interlaken Therapeutics, Inc. | Director since 2023 Age 68 Key Qualifications and Expertise: Our Board concluded that Mr. Heyman should continue to serve as a director of Exelixis due to his expertise in corporate development and his significant leadership experience in the biopharmaceutical sector, as well as his extensive experience serving on the boards of several public and private companies. Committee Assignments: •Governance Committee •Risk Committee (Chair Elect) Other Current Public Company Boards: •Akero Therapeutics, Inc., serving on the Audit Committee and Nominating and Corporate Governance Committee (Chair) •OptiNose, Inc., serving on the Nominating and Corporate Governance Committee •Invivyd, Inc., serving on the Audit Committee and Compensation Committee (Chair) (and has announced his intention not to seek re-election in 2024) •Legend Biotech Corporation •Xilio Therapeutics, Inc., serving on the Audit Committee and Nominating and Corporate Governance Committee (Chair) (and has announced his intention not to seek re-election in 2024) | |
Tomas J. Heyman has been a director since May 2023. Since 2021, Mr. Heyman has served as a consultant to Interlaken Therapeutics, Inc., a biotechnology company, and as its interim Chief Executive Officer, and since 2020, he has served as Operating Partner at Bioqube Ventures, a life sciences investment firm. Previously, Mr. Heyman served as the President of Johnson & Johnson’s Corporate Venture Capital Group, the venture capital arm of Johnson & Johnson, a pharmaceutical and consumer packaged goods company, from 2015 to 2019, and as the Global Head of Business Development for Johnson & Johnson’s Pharmaceutical Group from 1992 to 2015. In addition, he served as Managing Director of Janssen Pharmaceutica, a pharmaceutical NV, a pharmaceutical company and an affiliate of Johnson & Johnson (now known as Johnson & Johnson Innovative Medicine), from 2008 to 2016. Mr. Heyman began his career as a member of the legal department of Janssen Pharmaceutica NV in 1982. Mr. Heyman has served as Non-executive Chairman of the board of directors of Venatorx Pharmaceuticals, Inc., a privately held pharmaceutical company, since 2023. He has also served as a member of the board of directors of: Legend Biotech Corporation, a publicly held biotechnology company, since 2022; Xilio Therapeutics, Inc., a publicly held biotechnology company, since 2022 (and has announced his intention to not seek re-election in 2024); Invivyd, Inc. (formerly Adagio Therapeutics), a publicly held biopharmaceutical company, since 2021 (and has announced his intention to not seek re-election in 2024); OptiNose, Inc., a publicly held specialty pharmaceutical company, since 2020; and Akero Therapeutics, Inc., a publicly held biotechnology company, since 2020. Previously, Mr. Heyman served as a member of the Supervisory Board of Crucell NV, a biotechnology company. In addition to his private and public company experience, Mr. Heyman has served on the board of directors of the International Biomedical Research Alliance, a non-profit organization focused on biomedical research, since 2018, and as a member of the board of directors of Interuniversitair Micro-Electronica Centrum VZW, a Belgian non-profit organization specializing in micro- and nano-electronic research, since 2012. Mr. Heyman holds a Master of Laws from Katholieke Universiteit Leuven. He continued with post-graduate studies in International Law in Geneva, Switzerland, and post-graduate studies in Business Management at the University of Antwerp in Belgium. | ||
David E. Johnson Managing Partner and Chief Investment Officer, Caligan Partners LP | Director since 2023 Age 41 Key Qualifications and Expertise: Our Board concluded that Mr. Johnson should continue to serve as a director at Exelixis due to his expertise in strategic capital allocation and experience as an investor and director for various life sciences companies. Committee Assignments: •Audit Committee •Research & Development Committee Other Current Public Company Boards: •Liquidia Corporation, serving on the Audit Committee | |
David E. Johnson has been a director since May 2023. Since 2017, Mr. Johnson has served as the Managing Partner and Chief Investment Officer of Caligan Partners LP, an SEC-registered investment adviser. Previously, he served as Managing Director at the Carlyle Group, a global private equity, alternative asset management and financial services firm, from 2010 to 2017, and as Vice President in the Principal Investments area at Morgan Stanley, a global financial services and investment management firm, from 2004 to 2010. Prior to joining Morgan Stanley, Mr. Johnson worked at Weiss Asset Management, an investment management firm, from 2003 to 2004. Mr. Johnson has served as a member of the board of directors of Liquidia Corporation, a publicly held biopharmaceutical company, since 2021, and as a member of the board of directors of AMAG Pharmaceuticals, Inc., a publicly held pharmaceutical company specializing in products treating iron deficiency anemia, from 2019 until its acquisition by Covis Group S.à r.l. in 2020. In the not-for-profit sector, Mr. Johnson serves as a member of the board of directors of The Children’s Scholarship Fund, Inc., a privately funded tuition assistance program, and previously served on the Executive Committee for the Harvard College Fund. Mr. Johnson holds an A.B. and S.M. in Applied Mathematics from Harvard University. | ||
Proposal 1 | Director Nominees |
2024 Proxy Statement | 15 |
Michael M. Morrissey, Ph.D. President and Chief Executive Officer, Exelixis, Inc. | Director since 2010 Age 63 Key Qualifications and Expertise: Our Board concluded that Dr. Morrissey should continue to serve as a director of Exelixis due to his leadership role as the President and Chief Executive Officer of Exelixis. Beyond his role as Exelixis’ principal executive officer, the Board also considered Dr. Morrissey’s extensive qualifications, including his training as a scientist, his significant knowledge and experience with respect to the biotechnology, healthcare and pharmaceutical industries, comprehensive leadership background resulting from service as an executive in the biotechnology industry, and his ability to bring historic knowledge and continuity to the Board. Committee Assignments: •None Other Current Public Company Boards: •Vera Therapeutics, Inc. (Chair), serving on the Audit Committee and the Nominating and Corporate Governance Committee | |
Michael M. Morrissey, Ph.D., has served as a director and as Exelixis’ President and Chief Executive Officer since July 2010. Dr. Morrissey has held positions of increasing responsibility at Exelixis since he joined the company in February 2000, including serving as President of Research and Development from January 2007 to July 2010. From 1991 to 2000, Dr. Morrissey held several positions at Berlex Biosciences, last holding the position of Vice President, Discovery Research. Earlier in his career, Dr. Morrissey served as a Senior Scientist and Project Team Leader in Medicinal Chemistry at CIBA-Geigy Corporation. Dr. Morrissey has served as Chair of the board of directors of Vera Therapeutics, Inc., a publicly held, clinical-stage biotechnology company focused on developing and commercializing transformative treatments for patients with serious immunological diseases, since April 2022, and previously served as a member of the board of directors of XWPharma Ltd., a privately held, clinical-stage biopharmaceutical company dedicated to the discovery and development of novel therapeutics, from December 2020 to April 2023, and as a member of the board of directors of CERo Therapeutics, Inc., a privately held biopharmaceutical company focused on next-generation cell-based therapies for cancer, from January 2022 to November 2022. He is the author of numerous scientific publications in medicinal chemistry and drug discovery and an inventor on 70 issued U.S. patents and 25 additional published U.S. patent applications. Dr. Morrissey holds a B.S. (Honors) in Chemistry from the University of Wisconsin and a Ph.D. in Chemistry from Harvard University. | ||
Robert (Bob) L. Oliver, Jr. Executive Advisor | Director 2023 Age 65 Key Qualifications and Expertise: Our Board concluded that Mr. Oliver should continue to serve as a director of Exelixis due to his leadership experience and expertise in the field of pharmaceutical commercialization, his memberships on the boards of directors of various pharmaceutical and biotechnology companies and his extensive experience in financial strategy and business development. Committee Assignments: •Compensation Committee •Risk Committee Other Current Public Company Boards: •PsyBio Therapeutics Corp. | |
Robert L. Oliver, Jr. has been a director since May 2023. From 2010 to 2020, Mr. Oliver served in a variety of senior positions at Otsuka America Pharmaceutical, Inc., a pharmaceutical company and subsidiary of Otsuka Holdings Co. Ltd., including President and Chief Executive Officer from 2016 to 2017, President and Chief Operating Officer from 2014 to 2016, Vice President of Sales and Marketing from 2010 to 2014, and as Chairman of Otsuka Canada Pharmaceutical, Inc. from 2016 to 2020. Prior to joining Otsuka, he served in a variety of senior positions at Wyeth Pharmaceuticals, a pharmaceutical company, where he also served as Senior Vice President from 2008 to 2010 and Vice President from 2005 to 2008. Mr. Oliver began his career with Johnson & Johnson, a pharmaceutical and consumer packaged goods company, where he held a variety of positions from 1989 to 2005. In addition, Mr. Oliver has served as an Executive Advisor of CELLIX Biosciences, a biopharmaceutical company, since 2018, and Hyalo Technologies, LLC, since 2017. Mr. Oliver has served as a member of the board of directors of PsyBio Therapeutics Corp., a publicly held biotechnology company, since 2021, as a member of the board of directors of Neurotez, Inc., a privately held biotechnology company, since 2017, and as a member of the board of directors of Hyalo Technologies, LLC, a privately held biotechnology and biopharmaceutical company, since 2017. Previously, he served as a member of the board of directors and as Executive Advisor of Medison Canada, an affiliate of Medison Pharma Ltd., from 2018 to 2022, and as a member of the board of directors of Immunomedics, Inc., a publicly held biotechnology company, from January 2017 until its acquisition by Gilead Sciences, Inc. in March 2017. In the not-for- profit sector, Mr. Oliver serves on the Pharma Board of Advisors at Saint Joseph’s University and on the Board of Governors of the Accreditation Council for Medical Affairs. Mr. Oliver holds a B.A. from Rutgers University and an M.B.A. from Saint Joseph’s University. | ||
16 | Exelixis, Inc. |
Stelios Papadopoulos, Ph.D. Co-Founder and Chair of the Board, Exelixis, Inc. | Director since 1994 Age 75 Key Qualifications and Expertise: Our Board concluded that Dr. Papadopoulos should continue to serve as a director of Exelixis due to his training as a scientist, his knowledge and experience with respect to the biotechnology, healthcare and pharmaceutical industries, his broad leadership experience resulting from extensive service on various boards, his knowledge and experience with respect to finance matters, and his ability to bring historic knowledge and continuity to the Board. Committee Assignments: •Audit Committee •Compensation Committee •Research & Development Committee Other Current Public Company Boards: •Regulus Therapeutics, Inc. (Chair), serving on the Audit Committee and the Nominating and Governance Committee | |
Stelios Papadopoulos, Ph.D., a co-founder of Exelixis, has been a director since December 1994 and the Chair of the Board since January 1998. Dr. Papadopoulos retired as Vice Chairman of Cowen & Co., LLC in 2006 after six years as an investment banker with the firm, where he focused on the biotechnology and pharmaceutical sectors. Prior to joining Cowen & Co., he spent 13 years as an investment banker at PaineWebber, Incorporated, where he was most recently Chairman of PaineWebber Development Corp., a PaineWebber subsidiary focusing on biotechnology. He joined PaineWebber in 1987 from Drexel Burnham Lambert, where he was a Vice President in the Equity Research Department covering the biotechnology industry. Prior to Drexel, he was a biotechnology analyst at Donaldson, Lufkin & Jenrette. Before coming to Wall Street in 1985, Dr. Papadopoulos was on the faculty of the Department of Cell Biology at New York University Medical Center. Dr. Papadopoulos was a co-founder of Anadys Pharmaceuticals, Inc., a publicly held biopharmaceutical company dedicated to improving patient care by developing novel medicines for the treatment of hepatitis C, acquired by F. Hoffmann-La Roche Ltd. in 2011. Dr. Papadopoulos served as a member of the board of directors of Anadys Pharmaceuticals from 2000 to 2011 and as its Chairman in 2011, prior to its acquisition. Dr. Papadopoulos has served as a member of the board of directors of Regulus Therapeutics Inc., a publicly held biopharmaceutical company focused on the development of medicines targeting microRNAs, since 2008, and as its Chairman since 2013, as a member of the board of directors of Graviton Bioscience Corporation, a privately held biopharmaceutical company focused on novel therapeutics designed for the treatment of autoimmune, cancer, certain genetic, fibrotic, and other serious diseases, since September 2023, and as co-founder and Chairman of the board of directors of Epikast, Inc., a privately held company focused on providing sales, medical affairs, market access, patient engagement and other services to pharmaceutical companies, since June 2023. He previously served as a member of the board of directors of three other publicly held companies: Biogen, Inc., a biopharmaceutical company focused on the treatment of serious diseases, from 2008 to 2023, and as its Chairman from 2014 to 2023; Eucrates Biomedical Acquisition Corp., a special purpose acquisition company (SPAC) formed for the purpose of effecting a merger, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses, and as its Chairman, from 2020 to 2023; and BG Medicine, Inc., a diagnostics company focused on the development and commercialization of cardiovascular diagnostic tests, from 2003 until 2018. Dr. Papadopoulos was also co- founder and member of the board of directors of Cellzome Inc., a privately held drug discovery company acquired by GSK plc (formerly GlaxoSmithKline) in 2012. In the not- for-profit sector, Dr. Papadopoulos is a co-founder and Chairman of Fondation Santé, and until 2023, he served as a member of the board of visitors of Duke Medicine, and a member of the Global Advisory Board of the Duke Institute for Health Innovation. Dr. Papadopoulos holds an M.S. in Physics, a Ph.D. in Biophysics and an M.B.A. in Finance, all from New York University. | ||
Proposal 1 | Director Nominees |
2024 Proxy Statement | 17 |
George Poste, DVM, Ph.D., FRS Chief Scientist, Complex Adaptive Systems Initiative | Director since 2004 Age 79 Key Qualifications and Expertise: Our Board concluded that Dr. Poste should continue to serve as a director of Exelixis due to his training as a scientist, his knowledge and experience with respect to the life sciences, healthcare and pharmaceutical industries, his broad leadership experience resulting from service on various boards, and his knowledge and experience with policymaking, regulatory issues and other governmental matters. Committee Assignments: •Research & Development Committee (Chair) •Risk Committee Other Current Public Company Boards: •None | |
George Poste, DVM, Ph.D., FRS, has been a director since August 2004. Since 2009, Dr. Poste has been the Chief Scientist at Complex Adaptive Systems Initiative and Regents’ Professor and Del E. Webb Professor of Health Innovation at Arizona State University. From 2003 to 2009, Dr. Poste served as the director of the Biodesign Institute at Arizona State University. Dr. Poste has served as the Chief Executive Officer of Health Technology Networks, a consulting company that specializes in the application of genomic technologies and computing in healthcare, since 2000. From 1992 to 1999, he was the Chief Science and Technology Officer and President, R&D, of SmithKline Beecham Corporation, a pharmaceutical company (later merged into GlaxoSmithKline plc). Dr. Poste served on the Defense Science Board of the U.S. Department of Defense from 2001 to 2010 and is a member of other organizations dedicated to advancing defenses against bioweapons and biowarfare. Dr. Poste has served as a member of the board of directors of Caris Life Sciences, a privately held medical diagnostics company, since 2009, and as a member of the board of directors of MediSix Therapeutics Pte. Ltd. (Singapore), a privately held immune engineering company developing novel cellular therapies to address Ta cell malignancies, since 2022. Previously, Dr. Poste served as a member of the board of directors of InanoBio, Inc., a privately held biotechnology company, from 2021 to 2023, as a member of the board of directors of Monsanto Company, a publicly held provider of agricultural products and solutions, from 2003 until its acquisition by Bayer Aktiengesellschaft in 2018, and as the Non-executive Chairman of Orchid Cellmark, Inc., a publicly held DNA forensics company, from 2000 until its acquisition by the Laboratory Corporation of America in 2009. Dr. Poste is a Fellow of the Royal Society, the UK Academy of Medical Sciences, Hoover Institution, Stanford University, and various other prestigious organizations and has been awarded honorary doctorates from several universities. Dr. Poste holds a DVM in veterinary medicine and a Ph.D. in Virology from the University of Bristol, England and Board Certification in Pathology from the Royal College of Pathologists. | ||
18 | Exelixis, Inc. |
Julie Anne Smith Chief Executive Officer, Nuvig Therapeutics, Inc. | Director since 2016 Age 53 Key Qualifications and Expertise: Our Board concluded that Ms. Smith should continue to serve as a director of Exelixis due to her knowledge and experience with respect to biotechnology, healthcare and pharmaceutical industries and her broad leadership experience resulting from service as an executive in the pharmaceutical industry. Committee Assignments: •Audit Committee •Compensation Committee (Chair) Other Current Public Company Boards: •Stoke Therapeutics, Inc., serving on the Compensation Committee | |
Julie Anne Smith has been a director since September 2016. Since January 2023, Ms. Smith has served as Chief Executive Officer and a member of the board of directors of Nuvig Therapeutics, Inc., a privately held biopharmaceutical company developing proprietary recombinant human therapeutics for patients with autoimmune disease. Previously, Ms. Smith served as President and Chief Executive Officer and as a member of the board of directors of ESCAPE Bio Inc., a privately held, clinical-stage biopharmaceutical company developing novel, precisely targeted therapeutics for genetically defined neurodegenerative diseases, from 2018 to 2022, and as President and Chief Executive Officer and as a member of the board of directors of Nuredis, Inc., a privately held biotechnology company, from 2017 to 2018. Prior to Nuredis, she served as President and Chief Executive Officer of Raptor Pharmaceutical Corp., a publicly held biopharmaceutical company focused on developing and commercializing transformative treatments for people affected by rare and debilitating diseases, from 2015 until the company’s acquisition by Horizon Pharma plc in 2016, where she also served as Executive Vice President and Chief Operating Officer from 2012 to 2014. From 2008 to 2012, Ms. Smith served as Chief Commercial Officer of Enobia Pharmaceuticals prior to the company’s acquisition by Alexion Pharmaceuticals, Inc. Previously, Ms. Smith served as Vice President of Commercial at Jazz Pharmaceuticals plc from 2006 to 2008, as Vice President, Global Marketing at Genzyme General from 2001 to 2005, and helped to establish the operations and business development function for the biotech start-up, Novazyme Pharmaceuticals, from 2000 to 2001. Ms. Smith began her industry career at Bristol- Myers Squibb Company in 1996. Ms. Smith has served as a member of the board of directors of Stoke Therapeutics, Inc., a publicly held biotechnology company pioneering a new way to treat the underlying cause of genetic diseases by precisely unregulating protein expression, since 2020. Previously, Ms. Smith served as a member of the board of directors of Audentes Therapeutics, Inc. a publicly held, clinical-stage biotechnology company focused on developing and commercializing gene therapy products for patients suffering from serious, life-threatening rare diseases caused by single gene defects, from 2016 until its acquisition by Astellas Pharma Inc. in 2020, and as a Director on the Health and Emerging Companies Sections of the Biotechnology Innovation Organization (BIO) board. Ms. Smith holds a B.S. in biological and nutritional sciences from Cornell University. | ||
Jack L. Wyszomierski Former Executive Vice President and Chief Financial Officer, VWR International, LLC | Director since 2004 Age 68 Key Qualifications and Expertise: Our Board concluded that Mr. Wyszomierski should continue to serve as a director of Exelixis due to his extensive financial reporting, accounting, and finance experience, as well as his experience in the healthcare and life sciences industries. These qualities have also formed the basis for the Board’s decision to appoint Mr. Wyszomierski as a member and Chair of the Audit Committee. Committee Assignments: •Audit Committee (Chair) •Governance Committee Other Current Public Company Boards: •XOMA Corporation (chair), serving on the Audit Committee and the Compensation Committee •Athersys, Inc., serving on the Audit Committee, the Compensation Committee and the Nominations, Governance and Compliance Committee (Chair) •SiteOne Landscape Supply, Inc., serving on the Audit Committee and the Nominating & Corporate Governance Committee (Chair) | |
Jack L. Wyszomierski has been a director since February 2004. From 2004 to 2009, Mr. Wyszomierski served as the Executive Vice President and Chief Financial Officer of VWR International, LLC, a supplier of laboratory supplies, equipment and supply chain solutions to the global research laboratory industry. From 1982 to 2003, Mr. Wyszomierski held positions of increasing responsibility within the finance group at Schering-Plough Corporation, a health care company, culminating with his appointment as Executive Vice President and Chief Financial Officer in 1996. Prior to joining Schering-Plough, he was responsible for capitalization planning at Joy Manufacturing Company, a producer of mining equipment, and was a management consultant at Data Resources, Inc. Mr. Wyszomierski has served: as a member of the board of directors of XOMA Corporation, a publicly held biotech royalty aggregator, since 2010, and as its Chairman since January 2024; as a member of the board of directors of Athersys, Inc., a publicly held company engaged in the discovery and development of therapeutic product candidates, since 2010; and as a member of the board of directors of SiteOne Landscape Supply, Inc., a publicly held company that distributes landscape supply products, since 2016. Mr. Wyszomierski previously served as a member of the board of directors of: Unigene Laboratories, Inc., a publicly held biopharmaceutical company, from 2010 to 2013; AssuraMed Holding, Inc., a privately held distributor of home healthcare products, from 2011 until its acquisition by Cardinal Health Inc. in 2013; and Solenis, Inc., a privately held chemicals producer from 2014 until its acquisition by Platinum Equity in 2021. Mr. Wyszomierski holds a M.S. in Industrial Administration and a B.S. in Administration, Management Science and Economics from Carnegie Mellon University. | ||
THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” EACH NAMED NOMINEE. |
Proposal 1 | Director Nominees |
2024 Proxy Statement | 19 |
•Evaluating the performance, qualifications, compensation and continued engagement of the independent registered public accounting firm, as well as resolving any disagreements between the independent registered public accounting firm and management | •Reviewing the financial statements for inclusion in our Annual Report on Form 10-K and preparing the Audit Committee’s report for inclusion in our Proxy Statement or Annual Report on Form 10-K |
•Reviewing our tax strategy, material tax audits and proceedings and any other material tax matters | •Establishing procedures to receive and address complaints regarding accounting, internal accounting controls or auditing matters |
•Reviewing, overseeing and approving related person transactions | •Reviewing the results of the annual audit and the quarterly financial statement reviews with management and the independent registered public accounting firm |
•Overseeing our management of risks relating to financial reporting, fraud, securities trading and tax matters | •Maintaining compliance with SEC and Nasdaq rules applicable to audit committees |
•Serving as the Qualified Legal Compliance Committee within the meaning of Rule 205.2(k) of Title 17, Chapter II of the Code of Federal Regulations | •Reviewing and approving our decisions to enter into certain swaps and other derivatives transactions, as well as our overall hedging strategy |
20 | Exelixis, Inc. |
•Assessing compensation policies and practices and reviewing executive compensation | •Evaluating director compensation and recommending any changes to the Board for approval |
•Reviewing our Compensation Discussion and Analysis and preparing the Compensation Committee’s report for inclusion in our Proxy Statement | •Administering equity awards under our stock plans |
•Addressing any conflict of interest with any compensation adviser engaged by management or the Compensation Committee | •Assisting the Board in its oversight of our human capital management function, including recruiting, retention, career development and progression, non-CEO management succession and diversity |
•Establishing compensation and benefits policies for employees, including executive officers | •Overseeing annual evaluations of performance of our executive officers |
•Establishing, overseeing and reviewing stock ownership guidelines for directors and executive officers |
Proposal 1 | Board Committees |
2024 Proxy Statement | 21 |
•Overseeing our governance practices, including recommending to the Board for approval of any changes to our corporate governance framework | •Identifying, evaluating and recommending qualified director candidates to the Board |
•Ensuring effective communication between the Board, its committees and management, as well as establishing procedures for stockholders’ communications to the Board | •Developing Corporate Governance Guidelines and administering our Corporate Code of Conduct |
•Conducting periodic assessments of the performance of the Board and its committees and compliance with SEC and Nasdaq requirements for independence and expertise | •Conducting periodic assessments of sustainability strategy and policies (including ESG matters), and overseeing management in their implementation and the preparation of public disclosures pertaining to ESG programs and sustainability efforts |
•Facilitating CEO succession planning | •Overseeing the orientation program for new directors and continuing education of all directors |
22 | Exelixis, Inc. |
•Overseeing our clinical development program and internal drug discovery activities | •Reviewing the overall organization, resourcing and capabilities of our research and development business units |
•Reviewing the progress of preclinical and clinical assets that we have in-licensed or acquired and evaluating the scientific aspects of potential future business development opportunities | •Evaluating and discussing trends in the oncology treatment landscape and potential effects on our pipeline strategy and other business needs |
•Advising the Board on other matters of scientific importance as the Board, in consultation with management, may designate from time to time |
Proposal 1 | Board Committees |
2024 Proxy Statement | 23 |
•Reviewing our overall risk management framework and infrastructure designed to identify, assess, manage and mitigate our material risks | •Overseeing management’s administration of government and other investigations and material litigation matters |
•Overseeing management’s administration of our various compliance programs, including, but not limited to, those relating to data privacy and cybersecurity, drug safety, healthcare compliance and quality management | •Overseeing management’s identification, assessment and management of our business and operational risks not specifically allocated to the Board or another committee of the Board, and obtaining periodic reports from our Ethics Committee |
•Reviewing the policies, guidelines and practices for managing business and operational risks | •Evaluating trends in risk management and advising the Board on best practices with respect to risk management strategy and implementation |
Board of Directors | Audit Committee | Compensation Committee | Nominating and Corporate Governance Committee | Research & Development Committee | Risk Committee | |
Number of Meetings Held in Fiscal 2023 | 8 | 4 | 8 | 3 | 2 | 2 |
24 | Exelixis, Inc. |
Proposal 1 | Corporate Governance |
2024 Proxy Statement | 25 |
26 | Exelixis, Inc. |
Proposal 1 | Corporate Governance |
2024 Proxy Statement | 27 |
28 | Exelixis, Inc. |
Proposal 1 | Corporate Governance |
2024 Proxy Statement | 29 |
30 | Exelixis, Inc. |
Compensation of Directors |
2024 Proxy Statement | 31 |
Annual Cash Compensation ($) | |||
Service | Fee Type | Q1 – Q3 2023 | Q4 2023 |
Board | Retainer Fee | 55,000 | 60,000 |
Additional Chair Retainer Fee | 31,000 | 35,000 | |
Meeting Fee (1)(2) | 2,500 | N/A | |
Audit Committee | Retainer Fee | 12,000 | 15,000 |
Additional Chair Retainer Fee | 13,000 | 15,000 | |
Meeting Fee (1)(3) | 1,000 | N/A | |
Compensation Committee | Retainer Fee | 10,000 | 12,000 |
Additional Chair Retainer Fee | 10,000 | 13,000 | |
Meeting Fee (1)(3) | 1,000 | N/A | |
Nominating & Corporate Governance Committee | Retainer Fee | 5,000 | 12,000 |
Additional Chair Retainer Fee | 10,000 | 13,000 | |
Meeting Fee (1)(4) | 1,000 | N/A | |
Research & Development Committee | Retainer Fee | 5,000 | 12,000 |
Additional Chair Retainer Fee | 10,000 | 13,000 | |
Meeting Fee (1)(4) | 1,000 | N/A | |
Risk Committee | Retainer Fee | 5,000 | 12,000 |
Additional Chair Retainer Fee | 10,000 | 13,000 | |
Meeting Fee (1)(4) | 1,000 | N/A |
32 | Exelixis, Inc. |
Compensation of Directors |
2024 Proxy Statement | 33 |
Fees Earned or Paid in Cash ($) | Stock Awards ($)(1) | Option Awards ($)(2) | All Other Compensation ($)(3) | Total ($) | |
Carl B. Feldbaum, Esq. (4) | 37,500 | — | — | 50,000 | 87,500 |
Maria C. Freire, Ph.D. | 87,000 | 401,722 | — | 488,722 | |
Alan M. Garber, M.D., Ph.D. (5) | 80,500 | — | 400,667 | 481,167 | |
Tomas J. Heyman (6) | 37,250 | 350,433 | 328,508 | 716,191 | |
David E. Johnson (6) | 39,750 | 350,433 | 328,508 | 718,691 | |
Vincent T. Marchesi, M.D., Ph.D. (4) | 35,000 | — | — | 50,000 | 85,000 |
Robert L. Oliver, Jr. (6) | 38,500 | 350,433 | 328,508 | 717,441 | |
Stelios Papadopoulos, Ph.D. | 118,250 | 401,722 | — | 519,972 | |
George Poste, DVM, Ph.D., FRS | 80,500 | 401,722 | — | 482,222 | |
Julie A. Smith | 90,250 | — | 400,667 | 490,917 | |
Lance Willsey, M.D. (7) | 35,000 | — | — | 35,000 | |
Jacqueline Wright (5) | 69,750 | 401,722 | — | 471,472 | |
Jack L. Wyszomierski | 89,250 | 401,722 | — | 490,972 |
34 | Exelixis, Inc. |
Compensation of Directors | Director Compensation Table |
2024 Proxy Statement | 35 |
THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” PROPOSAL 2. |
36 | Exelixis, Inc. |
Fiscal Year Ended | ||
December 29, 2023 | December 30, 2022 | |
Audit fees (1) | $2,805,390 | $2,611,000 |
Audit-related fees (2) | 130,000 | 275,000 |
Tax fees: | 547,405 | 481,560 |
Tax compliance fees (3) | 259,100 | 246,735 |
Other tax fees (4) | 288,305 | 234,825 |
All other fees (5) | — | 2,000 |
Total Fees | $3,482,795 | $3,369,560 |
Proposal 2 | Ratification of Selection of Independent Registered Public Accounting Firm |
2024 Proxy Statement | 37 |
38 | Exelixis, Inc. |
Proposal 3 | Amendment and Restatement of the Exelixis, Inc. 2000 Employee Stock Purchase Plan |
2024 Proxy Statement | 39 |
40 | Exelixis, Inc. |
Proposal 3 | Amendment and Restatement of the Exelixis, Inc. 2000 Employee Stock Purchase Plan |
2024 Proxy Statement | 41 |
42 | Exelixis, Inc. |
Proposal 3 | Amendment and Restatement of the Exelixis, Inc. 2000 Employee Stock Purchase Plan |
2024 Proxy Statement | 43 |
Name and position | Number of shares |
Michael M. Morrissey, Ph.D. President and Chief Executive Officer | 2,056 |
Christopher J. Senner Executive Vice President and Chief Financial Officer | 10,464 |
Dana T. Aftab Executive Vice President, Discovery and Translational Research and Chief Scientific Officer | 73,752 |
Jeffrey J. Hessekiel, J.D. Executive Vice President, General Counsel and Secretary | 8,924 |
Amy C. Peterson, M.D. Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer | — |
Vicki L. Goodman, M.D. Former Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer | — |
All current executive officers as a group | 149,063 |
All current directors who are not executive officers as a group | — |
All employees, including all current officers who are not executive officers, as a group | 11,080,519 |
44 | Exelixis, Inc. |
Plan Category | Number of securities to be issued upon exercise of outstanding options, warrants and rights (a) | Weighted- average exercise price of outstanding options, warrants and rights (b) | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) (c) | |
Equity compensation plans approved by stockholders | 23,898 | $7.23 | 29,581 | |
Equity compensation plans not approved by stockholders | 75 | $20.61 | — | |
Total | 23,973 | $7.27 | 29,581 |
THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” PROPOSAL 3. |
Proposal 3 | Amendment and Restatement of the Exelixis, Inc. 2000 Employee Stock Purchase Plan |
2024 Proxy Statement | 45 |
THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” PROPOSAL 4. |
46 | Exelixis, Inc. |
Beneficially Owned (1) | ||
Name of Beneficial Owner | Number of Shares of Common Stock | Percentage of Total |
Named Executive Officers and Directors | ||
Michael M. Morrissey, Ph.D. (2) | 2,685,808 | * |
Christopher J. Senner (3) | 679,766 | * |
Dana T. Aftab, Ph.D. (4) | 406,671 | * |
Jeffrey J. Hessekiel, J.D. (5) | 598,161 | * |
Amy C. Peterson, M.D. (6) | — | * |
Vicki L. Goodman, M.D. (7) | 61,271 | * |
Mary C. Beckerle, Ph.D. (8) | 30,848 | * |
S. Gail Eckhardt, M.D. (9) | 30,848 | * |
Maria C. Freire, Ph.D. (10) | 156,503 | * |
Alan M. Garber, M.D., Ph.D. (11) | 279,524 | * |
Tomas J. Heyman (12) | 36,353 | * |
David E. Johnson (13) | 1,137,083 | * |
Robert L. Oliver, Jr. (14) | 36,353 | * |
Stelios Papadopoulos, Ph.D. (15) | 1,287,805 | * |
George Poste, DVM, Ph.D., FRS (16) | 241,383 | * |
Julie A. Smith (17) | 216,533 | * |
Jacqueline Wright (18) | 82,685 | * |
Jack L. Wyszomierski (19) | 397,715 | * |
All current directors and executive officers as a group (18 persons) (20) | 8,638,652 | 2.85% |
5% Stockholders | ||
BlackRock, Inc. (21) 55 East 52nd Street New York, New York 10055 | 36,013,885 | 12.0% |
The Vanguard Group (22) 100 Vanguard Blvd. Malvern, Pennsylvania 19355 | 31,671,090 | 10.6% |
Farallon Capital Partners, L.P. (23) One Maritime Plaza San Francisco, California 94111 | 25,860,000 | 8.6% |
Renaissance Technologies LLC (24) 800 Third Avenue New York, New York 10022 | 15,615,716 | 5.2% |
Security Ownership of Certain Beneficial Owners and Management |
2024 Proxy Statement | 47 |
48 | Exelixis, Inc. |
Security Ownership of Certain Beneficial Owners and Management |
2024 Proxy Statement | 49 |
Name | Age | Position |
Michael M. Morrissey, Ph.D. (1) | 63 | President and Chief Executive Officer |
Christopher J. Senner | 56 | Executive Vice President and Chief Financial Officer |
Dana T. Aftab, Ph.D. | 61 | Executive Vice President, Discovery and Translational Research and Chief Scientific Officer |
Patrick J. Haley | 48 | Executive Vice President, Commercial |
Jeffrey J. Hessekiel, J.D. | 55 | Executive Vice President, General Counsel and Secretary |
Amy C. Peterson, M.D. | 57 | Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer |
Christopher J. Senner Executive Vice President and Chief Financial Officer |
Christopher J. Senner, has served as Executive Vice President and Chief Financial Officer (and in such capacity, as our principal financial officer and principal accounting officer, as defined under applicable securities laws) since July 2015. Prior to joining Exelixis, Mr. Senner served as Vice President, Corporate Finance for Gilead Sciences, Inc., a biopharmaceutical company, from March 2010 to July 2015, where he was accountable for controllership, tax, treasury and corporate and operational financial planning. Mr. Senner previously spent eighteen years at Wyeth, a pharmaceutical company acquired by Pfizer Inc. in 2009, in a variety of financial roles with increasing responsibility, most notably as Chief Financial Officer of Wyeth’s U.S. pharmaceuticals business and the BioPharma Business Unit. Since 2019, Mr. Senner has served as a member of the board of directors of Quince Therapeutics, Inc. (f/k/a Cortexyme, Inc.), a publicly held clinical-stage biopharmaceutical company. Mr. Senner holds a B.S. in Finance from Bentley College. |
Dana T. Aftab, Ph.D. Executive Vice President, Discovery and Translational Research and Chief Scientific Officer |
Dana T. Aftab, Ph.D., has served as Executive Vice President, Discovery and Translational Research and Chief Scientific Officer at Exelixis since December 2022. Previously, he served as Executive Vice President, Business Operations from February 2016 to December 2022, during which time he oversaw the company’s corporate site development and campus operations, including the opening of new laboratory buildings at Exelixis’ Alameda campus and the ongoing buildout of the company’s Exelixis East footprint in the Greater Philadelphia area. Dr. Aftab first joined Exelixis in 1998, starting in Exelixis’ Drug Discovery organization, where he led teams that drove the discovery and development of the company’s approved medicines, including cabozantinib. In 2007, he moved into the company’s clinical development organization, where he led the effort to streamline Exelixis’ processes for transitioning drug discovery programs into clinical development, serving as Senior Vice President, Translational Research from 2009 to 2016. Prior to joining Exelixis, Dr. Aftab held senior scientist positions at several biotech start-ups. Dr. Aftab holds B.A. and Ph.D. degrees in pharmacology from the University of California, Santa Barbara and Yale University, respectively, and did his postdoctoral work at the University of California, Berkeley in the field of oncogene signaling. |
50 | Exelixis, Inc. |
Patrick J. Haley Executive Vice President, Commercial |
Patrick J. Haley, has served as the company’s Executive Vice President, Commercial since February 2020 and has held positions of progressive commercial leadership since September 2010, serving as Senior Vice President, Commercial from December 2016 to February 2020, Vice President, Commercial from November 2014 to November 2016, Executive Director, Sales & Marketing from September 2013 to October 2014, Senior Director, Marketing from March 2012 to August 2013, and as Director, Marketing from September 2010 to February 2012. Prior to joining Exelixis, from 2007 to 2010, he held positions of increasing responsibility at Genentech, Inc., on the Avastin marketing team, most recently Group Product Manager. Between 2003 and 2007, Mr. Haley served in various sales and marketing roles at Amgen, Inc. He served as an analyst at PWC Securities, Lehman Brothers and Accenture from 1998 to 2001. Mr. Haley holds a Masters of Business Administration from University of Michigan, Ross School of Business, and a Bachelor of Arts in Art History and Medieval and Renaissance Studies from Duke University. |
Jeffrey J. Hessekiel, J.D. Executive Vice President, General Counsel and Secretary |
Jeffrey J. Hessekiel, J.D., has served as Executive Vice President and General Counsel since February 2014, and as Secretary from October 2014 to September 2017, before resuming in January 2022. From 2012 to 2014, he held the position of Senior Counsel at Arnold & Porter Kaye Scholer LLP, where he advised emerging growth and public companies, primarily in the life sciences sector, on complex legal issues connected with strategic transactions, healthcare compliance programs and investigations, and regulatory matters. Prior to working with Arnold & Porter, from 2002 to 2012, he held positions of increasing responsibility at Gilead Sciences, Inc., most recently as Chief Compliance & Quality Officer where he was responsible for the creation and management of Gilead’s Corporate Compliance & Quality department. From 1998 to 2002, Mr. Hessekiel held the position of Associate, working on both litigation and corporate matters for Wilson Sonsini Goodrich and Rosati PC. Mr. Hessekiel also worked as an Associate focusing on litigation matters for Heller Ehrman LLP from 1996 to 1998. Prior to joining Heller Ehrman LLP, Mr. Hessekiel also worked for several international non-governmental organizations. Mr. Hessekiel received his J.D. from The George Washington University Law School and is admitted to practice in California. Mr. Hessekiel received a B.A. in Political Science from Duke University. |
Amy C. Peterson, M.D. Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer |
Amy Peterson, M.D., has served as Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer at Exelixis since August 2023. Dr. Peterson is an oncologist and veteran drug development leader with nearly two decades of experience advancing therapies for people with cancer. Prior to joining Exelixis, from October 2019 to September 2022, she served as Executive Vice President and Chief Development Officer and then as President and Chief Operating Officer at CytomX Therapeutics, Inc. Previously, from August 2016 to February 2019, Dr. Peterson served as Chief Medical Officer of Immuno-oncology at BeiGene, Inc., where she built the company’s development organization with oversight of all assets in solid tumor indications, including the checkpoint inhibitor tislelizumab. Prior to BeiGene, from August 2011 to July 2016, she was Vice President of Clinical Development at Medivation, Inc., where she contributed to the development of enzalutamide (XTANDI®) in prostate cancer and led breast cancer development for both enzalutamide and talazoparib (TALZENNA®). Dr. Peterson began her industry career at Genentech, Inc., where, from September 2005 to August 2011, she oversaw the development of early-stage molecules targeting multiple major pathways in oncology, and worked on many approved agents including bevacizumab (AVASTIN®), atezolizumab (TECENTRIQ®) and cobimetinib (COTELLIC®). In the not-for-profit sector, she serves as the Secretary of the Board of Directors of Conquer Cancer Foundation. Dr. Peterson received her M.D. from Thomas Jefferson University before completing a residency in internal medicine at Northwestern Memorial Hospital and a fellowship in hematology/oncology at the University of Chicago. |
Information about our Executive Officers |
2024 Proxy Statement | 51 |
Our 2023 NEOs | Title |
Michael M. Morrissey, Ph.D. | President and Chief Executive Officer |
Christopher J. Senner | Executive Vice President and Chief Financial Officer |
Dana T. Aftab, Ph.D. | Executive Vice President, Discovery and Translational Research and Chief Scientific Officer |
Jeffrey J. Hessekiel, J.D. | Executive Vice President, General Counsel and Secretary |
Amy C. Peterson, M.D. (1) | Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer |
Vicki L. Goodman, M.D. (2) | Former Executive Vice President, Product Development and Medical Affairs and Chief Medical Officer |
52 | Exelixis, Inc. |
We made significant progress with our product pipeline in 2023 and delivered strong financial results, bolstered by the performance and continued growth of the cabozantinib franchise as a leading therapy for forms of renal, liver and thyroid cancer. |
2023 Financial and Commercial Highlights | ||
$1.8 billion Total Revenues, representing 14% growth year-over-year | 7 Full years of operating profit | 39% CABOMETYX continued to have leading market position among tyrosine kinase inhibitors, with a total prescriptions (TRx) market share of 39% at the end of 2023 |
Returned capital to our stockholders through completion of $550 million share repurchase program Announced new $450 million share repurchase program for 2024 to continue returning capital to our stockholders |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 53 |
Key Business Performance Highlights Delivering on strategic objectives | |
2 Positive top-line results (TLR) in cabozantinib pivotal trials | ›› CONTACT-02: Announced in August 2023, CONTACT-02 met one of two primary endpoints, demonstrating a statistically significant and clinically meaningful improvement in progression- free survival (PFS) in patients with metastatic castration-resistant prostate cancer and soft- tissue disease who have progressed after treatment with one prior novel hormonal therapy. The phase 3 trial continues to the next planned overall survival analysis, anticipated in 2024, and we are discussing a potential regulatory submission with the FDA this year. If approved, we believe the combination would represent a compelling and novel option for patients with a poor prognosis and high unmet need. ›› CABINET: In October 2023, we presented detailed results that demonstrated cabozantinib provided dramatic improvements in PFS in two cohorts of patients with previously treated neuroendocrine tumors: one cohort of patients with advanced pancreatic neuroendocrine tumors (pNET) and a second cohort of patients with advanced extra-pancreatic NET (epNET). We are discussing these results with the FDA for a potential regulatory submission in 2024. If approved, we believe that cabozantinib would represent a new treatment option for patients with previously treated pNET or epNET. |
2 New clinical trials evaluating zanzalintinib: STELLAR-305 and STELLAR-009 | We made substantial progress expanding the clinical development of zanzalintinib, a novel, potent, third-generation oral tyrosine kinase inhibitors (TKI) that targets VEGF receptors, MET and the TAM kinases (TYRO3, AXL and MER) implicated in cancer’s growth and spread. ›› STELLAR-305: a phase 2/3 pivotal trial will evaluate zanzalintinib in combination with pembrolizumab, an immune checkpoint inhibitor developed by Merck & Co., Inc., versus monotherapy pembrolizumab in patients with previously untreated PD-L1-positive recurrent or metastatic squamous cell cancers of the head and neck (SCCHN) ›› STELLAR-009: an open-label phase 1b/2 trial evaluating zanzalintinib in combination with AB521, an inhibitor of the transcription factor HIF-2α developed by Arcus Biosciences, Inc., in patients with advanced solid tumors, including clear cell RCC |
2 New pipeline clinical trial programs: ADU-1805 and XL309 | ›› In February 2023, the FDA cleared the initial investigational new drug application (IND) for ADU-1805, a clinical-stage and potentially best-in-class monoclonal antibody that targets SIRPα. ADU-1805 is currently being evaluated in a phase 1 clinical trial to explore its pharmacokinetics, safety, tolerability and preliminary anti-tumor activity in patients with advanced solid tumors. ›› In September 2023, we acquired global rights to develop and commercialize XL309, a potentially best-in-class small molecule inhibitor of USP1. We are advancing the phase 1 development of XL309 as a potential therapy for tumors that have become refractory to PARP inhibitor (PARPi) therapy, including forms of ovarian, breast and prostate cancers, and will pursue potential PARPi combinations. |
6 Development candidates (DCs) advancing towards IND submissions in 2024 through 2026 | During 2023, we advanced multiple DCs toward potential IND filings in 2024 - 2026: ›› XB010, our first ADC advanced internally that targets the tumor antigen 5T4 ›› XB628, a bispecific antibody that targets PD-L1 and natural killer cell receptor group 2A ›› XL495, a small molecule inhibitor of protein kinase membrane associated tyrosine/ threonine 1 ›› XB371, a next-generation tissue factor-targeting ADC that is differentiated from XB002 by its topoisomerase inhibitor payload ›› XB064, a high-affinity monoclonal antibody targeting immunoglobin-like transcript 2, which is associated with resistance to PD-1 pathway inhibitors ›› XB033, an ADC targeting the tumor antigen IL13Rα2 |
54 | Exelixis, Inc. |
Key Compensation Actions | Description | |
Approved Salary Increases for NEOs | In February 2023, the Compensation Committee increased base salaries for our NEOs (other than Dr. Peterson) by between 3.5% and 4.0% over salaries of 2022. | |
Approved Annual Cash Bonuses That Are Aligned with Company Performance | In February 2024, the Compensation Committee approved annual cash bonus payments in amounts between 80% and 101% of each NEO’s 2023 target cash bonus amount. These decisions reflect the Compensation Committee’s assessment of the overall achievement of our pre-determined 2023 corporate goals, and the individual contributions of each NEO (other than Dr. Morrissey) toward the achievement of our corporate goals. | |
Granted Performance-Based and Time-Based Awards under Our Long- Term Incentive Program (LTIP) | In February 2023, the Compensation Committee approved equity awards for each NEO (other than Dr. Peterson) comprising approximately 50% performance-based RSU awards (PSUs) and 50% time-based RSU awards. The Compensation Committee believes this allocation between PSUs and RSUs provides an effective balance between retention and performance, risk and leverage, as well as alignment with the interests of stockholders and creating long-term value. | |
Did Not Adjust Performance Targets for LTIP or Annual Cash Bonus Plan | The Compensation Committee believes that the performance targets reflect critical business objectives for the company and that the programs as originally established remained appropriate. Consequently, the Compensation Committee did not adjust the performance targets for awards issued under our LTIP or our Annual Cash Bonus Plan in 2023. |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 55 |
Pay for Performance | ›› NEO compensation is closely linked to our corporate performance |
Stockholder Alignment | ›› Long-term equity incentives align the long-term financial interests of our NEOs with those of our stockholders |
Compensation Governance | ›› Our Compensation Committee is made up entirely of independent directors and engages an independent compensation consultant to advise on executive compensation matters |
Stockholder Feedback | ›› We value and regularly solicit stockholder feedback, including through an annual stockholder advisory vote to approve our executive compensation program (referred to herein as Say on Pay) |
Recoupment or Clawback Policy | ›› We maintain a Policy for Recoupment of Variable Compensation (referred to herein as the Clawback Policy) that permits the company to recoup variable compensation from senior level employees, including our NEOs, in the event of misconduct that causes material harm to the company ›› NEW: In September 2023, we amended and restated our Clawback Policy in accordance with the Dodd-Frank Wall Street Reform and Consumer Protection Act to provide for recovery of incentive-based compensation erroneously received by current or former executive officers, including our NEOs, following a restatement of financial results |
Annual Cash Bonus Amounts Subject to Payment Maximums | ›› Our Annual Cash Bonus Plan sets a cap of 200% on the payouts of target bonus payments for individual and/or corporate performance |
Equity Plan Features | ›› The 2017 Plan includes minimum vesting requirements of no less than one year for all types of awards, subject to limited exceptions ›› Applies a maximum 7-year term for stock options ›› Prohibits repricing of underwater stock options without prior stockholder approval |
Stock Ownership Guidelines | ›› We apply, monitor and enforce stock ownership guidelines to directors and executive officers to further align their interests with those of our stockholders ›› NEW: In September 2023, we amended our stock ownership guidelines to increase the target value for the Chief Executive Officer to 6 times his annual base salary |
Change in Control Provisions | ›› Does not include excessive change in control or severance payments ›› Provides “double-trigger” change in control benefits ›› Does not include Code Section 280G tax gross-ups on severance or change in control benefits |
Perquisites, Retirement and Pension Benefits | ›› Our NEOs do not receive excessive perquisites or post-termination retirement or pension benefits that are not available to all employees generally |
Prohibition on Hedging and Margin Loans | ›› We prohibit hedging and purchases on margin by executive officers and directors |
Meaningful Limits on Pledging | ›› We limit pledging of our common stock by executive officers and directors to circumstances where the individual can clearly demonstrate the financial capacity to repay the loan without resorting to the pledged securities ›› No executive officers or directors pledged our common stock during 2023 |
Compensation Risk Assessment | ›› Our Compensation Committee annually assesses the risks associated with our compensation policies and practices to ensure that our programs are not reasonably likely to have a material adverse effect on the company |
56 | Exelixis, Inc. |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 57 |
Range of Governance and Business Topics Discussed with Stockholders During 2023 |
›› Board Independence, Composition, Tenure and Refreshment |
›› Business Performance and Corporate Strategy |
›› ESG Disclosures |
›› DEI |
›› Executive Compensation |
›› Human Capital Management |
58 | Exelixis, Inc. |
Our Fiscal 2023 Peers (1) | ||
ACADIA Pharmaceuticals Inc. | Exact Sciences Corporation | Neurocrine Biosciences, Inc. |
Alkermes plc | Horizon Therapeutics plc | NovoCure Limited |
Alnylam Pharmaceuticals, Inc. | Incyte Corporation | Sarepta Therapeutics, Inc. |
BeiGene, Ltd. | Ionis Pharmaceuticals, Inc. | Seagen Inc. |
BioMarin Pharmaceutical Inc. | Jazz Pharmaceuticals plc | Ultragenyx Pharmaceutical Inc. |
Blueprint Medicines Corporation | Natera, Inc. | United Therapeutics Corporation |
Revenues | ||||
Market Capitalization |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 59 |
0 | 25th | 50th | 75th | 100th |
Element | Description | Objective(s) | |
Annual Base Salary | Annual fixed cash compensation | Provide a predictable level of income that is competitive with our Peers | |
Annual Cash Bonus | Variable cash compensation based on corporate performance, including achievement against pre-determined corporate goals and the individual contributions of each NEO toward the achievement of such corporate goals | Align our executive compensation with our annual corporate goals Motivate and reward achievement of corporate goals and overall company performance, including through individual contributions | |
Long-Term Incentive Compensation | RSUs (or PSUs, if performance- based) | Variable share-based compensation, subject to either time-based yearly vesting over four years or performance-based vesting based on the achievement of key corporate goals PSUs generally have a three-year performance period, with 50% of the earned PSUs vesting upon the Compensation Committee’s certification, and the remaining 50% vesting on the first quarterly vesting date following the one-year anniversary of the Compensation Committee’s certification | Align the interests of our executives with those of our stockholders Motivate our executives to achieve long-term corporate performance objectives Promote retention, including during periods of stock price volatility common to biotechnology companies |
Stock Options | Variable share-based compensation with value derived from appreciation in our company’s stock price | Align the interests of our executives with those of our stockholders Motivate our executives to achieve critical business objectives as stock options only have value if the value of our company as reflected by our stock price increases over time |
60 | Exelixis, Inc. |
Element | Description |
401(k) Plan | All employees, including NEOs, may contribute their own funds, as salary deductions, on a pre-tax or after-tax basis, subject to plan and government limits. For 2023, we matched pre-tax and Roth 401(k) contributions dollar-for-dollar up to $11,000. |
Employee Stock Purchase Plan | Our ESPP allows all employees, including NEOs, to purchase shares of our common stock at a price equal to the lower of 85% of the closing price on the first day of the six-month offering period or 85% of the closing price on the final day of such offering period, subject to specified limits. This year, we are requesting stockholder support for our proposal to increase the number of shares available under our ESPP so that we may continue to offer this valuable program to our employees. |
Health Care, Dental and Vision Benefits | Subject to applicable laws, these health and welfare benefits are available to all eligible employees, including NEOs. |
CIC Plan (1) | Participants receive certain plan benefits only if terminated without cause or constructively terminated, whether or not in connection with a change-in-control event. In the context of a change in control, our plan requires a “double-trigger” – participants are protected in the event of a termination without cause or constructive termination in connection with a change-in-control event, but they are encouraged to stay throughout a transition period in the event of a change in control, and the CIC Plan does not provide for benefits for a participant who remains with the surviving company in a comparable position. To serve our best interests, the plan requires a release of claims against us as a condition to receiving any severance benefits. |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 61 |
Name | 2022 Base Salary | 2023 Base Salary | Percentage Increase | ||
Michael M. Morrissey, Ph.D. | $1,155,039 | $1,201,241 | 4.0% | ||
Christopher J. Senner | $723,571 | $752,514 | 4.0% | ||
Dana T. Aftab, Ph.D. | $560,000 | $582,400 | 4.0% | ||
Jeffrey J. Hessekiel, J.D. | $636,797 | $662,269 | 4.0% | ||
Amy C. Peterson, M.D. (1) | N/A | $640,000 | N/A | ||
Vicki L. Goodman, M.D. (2) | $650,000 | $672,750 | 3.5% |
62 | Exelixis, Inc. |
NEO | 2023 Bonus Target |
Michael M. Morrissey, Ph.D. | 100% |
Christopher J. Senner | 50% |
Dana T. Aftab, Ph.D. | 50% |
Jeffrey J. Hessekiel, J.D. | 50% |
Amy C. Peterson, M.D. (1) | 50% |
Vicki L. Goodman, M.D. (2) | 50% |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 63 |
Corporate Goals | Weighting (%) | NEO | Weighting of Corporate Goals | Weighting of Individual Performance Assessment | |
Cabozantinib | 30% | Michael M. Morrissey, Ph.D. | 100% | 0% | |
Zanzalintinib | 20% | Christopher J. Senner | 70% | 30% | |
XB002 | 15% | Dana T. Aftab, Ph.D. | 70% | 30% | |
XL102 | 5% | Jeffrey J. Hessekiel, J.D. | 70% | 30% | |
Clinical Collaborations | 10% | Amy C. Peterson, M.D. (1) | 70% | 30% | |
Business Development | 10% | Vicki L. Goodman, M.D. (2) | 70% | 30% | |
IND Candidates | 5% | ||||
New DCs | 5% | ||||
Total | 100% |
64 | Exelixis, Inc. |
PERFORMANCE OBJECTIVES | ACHIEVEMENTS | TARGET % | ACHIEVEMENT % (1) | ||
Cabozantinib | 30% | 35% | |||
Target | Maximum | ||||
Achieve up to three TLRs from pivotal trials | Present up to two TLRs at major medical meeting | ›› Achieved four TLRs in cabozantinib pivotal trials: CONTACT-03; CONTACT-02; COSMIC-313 (second interim analysis of OS); CABINET ›› Presented two TLRs at ASCO 2023 (CONTACT-03) and ESMO 2023 (CABINET) | |||
Maximum Achievement | |||||
Meet the cabozantinib franchise net product revenues target | Exceed 105% of the cabozantinib franchise net product revenue target in the U.S. | ›› Achieved just below the cabozantinib franchise net product revenues target | |||
Below Target Achievement | |||||
Effectively prosecute and assert the cabozantinib patent estate against all challengers | Favorably resolve litigation with MSN Laboratories Private Ltd. (MSN), resulting in a loss of exclusivity for cabozantinib no earlier than 2030 | ›› Effectively prosecuted and asserted the cabozantinib patent estate through and beyond the October 2023 bench trial against MSN and its affiliates ›› Settled litigation with Teva Pharmaceutical Industries Limited (Teva) and its affiliates | |||
Target Achievement | |||||
Zanzalintinib | 20% | 13% | |||
Target | Maximum | ||||
Achieve enrollment targets for STELLAR-303 and STELLAR-304 pivotal trials | Achieve additional STELLAR-303 and STELLAR-304 enrollment targets | ›› STELLAR-303: Exceeded enrollment target. ›› STELLAR-304: Below enrollment target. | |||
Below Target Achievement | |||||
Initiate two new pivotal trials | Initiate three new pivotal trials | ›› Initiated one new pivotal trial (STELLAR-305) | |||
Below Target Achievement | |||||
XB002 | 15% | 6% | |||
Target | Maximum | ||||
Initiate cohort expansion phase of ongoing Phase 1 JEWEL-101 trial and achieve enrollment target | Achieve additional JEWEL-101 enrollment target | ›› Initiated JEWEL-101 cohort expansion phase ›› Achieved near target enrollment | |||
Below Target Achievement | |||||
Expand one additional JEWEL-101 cohort beyond the initial protocol expansions | Expand two additional JEWEL-101 cohorts beyond the initial protocol expansions | ›› No JEWEL-101 cohorts expanded beyond initial protocol expansions during 2023 | |||
Below Target Achievement |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 65 |
PERFORMANCE OBJECTIVES | ACHIEVEMENTS | TARGET % | ACHIEVEMENT % (1) | ||
XL102 | 5% | 4% | |||
Target | Maximum | ||||
Complete dose escalation of ongoing phase 1 QUARTZ-101, initiate cohort expansion stage and initiate one or more combination cohorts) | N/A | ›› Completed dose escalation of QUARTZ-101 | |||
Below Target Achievement | |||||
Go/No-Go decision for continuing development by end of 2023. | Go/No-Go decision for continuing development by the third quarter of 2023 | ›› Announced termination of XL102 development program in December 2023 | |||
Target Achievement | |||||
Clinical Collaborations | 10% | 8% | |||
Target | Maximum | ||||
Cybrexa Therapeutics (CBX-12): Advance ongoing CBX-12 phase 1 clinical trial and begin enrolling dose- expansion cohorts | CBX-12 opt-in decision during 2023 | ›› CBX12-101 study advanced during 2023 with focus on dose escalation | |||
Below Target Achievement | |||||
Sairopa B.V. (ADU-1805): Submit IND for ADU-1805 to FDA and advance program into phase 1 clinical trial | ADU-1805 opt-in decision during 2023 | ›› IND clearance announced in February 2023, and phase 1 trial is ongoing | |||
Target Achievement | |||||
Business Development | 10% | 3% | |||
Target | Maximum | ||||
Complete three transactions for oncology assets that are at or near clinical stage | Complete four transactions for oncology assets that are at or near clinical stage and two transactions for preclinical oncology assets or technology platforms | ›› Completed one transaction for oncology assets at or near clinical stage | |||
Below Target Achievement | |||||
IND Candidates | 5% | 5% | |||
Target | Maximum | ||||
Submit two new INDs to FDA from either internal research and development efforts or existing/new collaborations | Submit three new INDs to FDA from internal research and development efforts or existing/new collaborations | ›› ADU-1805: IND clearance announced in February 2023 ›› XL309: Active IND in May 2023 | |||
Target Achievement | |||||
New DCs | 5% | 6% | |||
Target | Maximum | ||||
Advance three programs to DC status | Advance five programs to DC status | ›› Declared and advanced four new DCs | |||
Above Target Achievement | |||||
100% | 80% |
66 | Exelixis, Inc. |
Name | 2023 Base Salary ($) | 2023 Target Award (%) | 2023 Corporate Performance Weighting (%) | 2023 Approved Corporate Performance (%) | 2023 Individual Performance Weighting (%) | 2023 Individual Performance (%) | 2023 Annual Cash Bonus Payout (% of Target Award) | 2023 Annual Cash Bonus Payout ($) |
Michael M. Morrissey, Ph.D. | $1,201,241 | 100% | 100% | 80% | N/A | N/A | 80% | $960,993 |
Christopher J. Senner | $752,514 | 50% | 70% | 80% | 30% | 80% | 80% | $301,006 |
Dana T. Aftab, Ph.D. | $582,400 | 50% | 70% | 80% | 30% | 150% | 101% | $294,112 |
Jeffrey J. Hessekiel, J.D. | $662,269 | 50% | 70% | 80% | 30% | 80% | 80% | $264,908 |
Amy C. Peterson, M.D. (1) | $640,000 | 50% | 70% | 80% | 30% | 80% | 80% | $256,000 |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 67 |
68 | Exelixis, Inc. |
2023 Relative TSR Goal | ||
Performance Level | Relative TSR Percentile v. Nasdaq Biotechnology Index Companies | PSUs Vesting as a Percentage of Target |
Below Threshold | 49th percentile or below | 0% |
Threshold | 50th percentile – 64th percentile | 50% |
Target | 65th percentile – 79th percentile | 100% |
Maximum | 80th percentile or above | 175% |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 69 |
Name | Number of Shares Subject to RSUs | Target Number of Shares Subject to 2023 PSUs |
Michael M. Morrissey, Ph.D. | 313,185 | 313,185 |
Christopher J. Senner | 85,414 | 85,414 |
Dana T. Aftab, Ph.D. | 68,331 | 68,331 |
Jeffrey J. Hessekiel, J.D. | 79,719 | 79,719 |
Amy C. Peterson, M.D. (1) | — | — |
Vicki L. Goodman, M.D. (2) | 82,566 | 82,566 |
70 | Exelixis, Inc. |
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 71 |
Position | Ownership Level |
Chief Executive Officer | NEW: Value equivalent to 6 times annual base salary |
Other NEOs | Value equivalent to 3 times annual base salary |
72 | Exelixis, Inc. |
Misconduct | Material Harm | |
Commits a knowing violation of a company policy or SEC rules or regulations; or Engages in the willful commission of an act of fraud, dishonesty or gross recklessness in the performance or disregard of their duties | Misconduct contributes or could reasonably be expected to contribute to the material harm of our business. | |
AND | ||
Compensation of Executive Officers | Compensation Discussion and Analysis |
2024 Proxy Statement | 73 |
74 | Exelixis, Inc. |
Name and Principal Position | Year (1) | Salary ($)(2) | Bonus ($)(3) | Stock Awards ($)(4) | Option Awards ($)(5) | Non-Equity Incentive Plan Compensation ($)(6) | All Other Compensation ($) (7) | Total ($) | ||
Michael M. Morrissey, Ph.D. | 2023 | 1,192,001 | — | 14,259,313 | — | 960,993 | 11,000 | 16,423,307 | ||
President and Chief | 2022 | 1,144,250 | — | 14,567,256 | — | 1,155,039 | 11,000 | 16,877,545 | ||
Executive Officer | 2021 | 1,093,875 | — | — | 5,160,513 | 1,265,043 | 11,000 | 7,530,431 | ||
Christopher J. Senner | 2023 | 746,726 | — | 3,888,899 | — | 301,006 | 11,000 | 4,947,631 | ||
Executive Vice President | 2022 | 716,172 | — | 4,093,312 | — | 361,786 | 11,000 | 5,182,270 | ||
and Chief Financial Officer | 2021 | 679,568 | — | 1,367,037 | — | 399,507 | 11,000 | 2,457,112 | ||
Dana T. Aftab, Ph.D. | 2023 | 577,920 | — | 4,770,110 | — | 294,112 | 11,000 | 5,653,142 | ||
Executive Vice President, | ||||||||||
Discovery and Translational Research and Chief Scientific Officer | ||||||||||
Jeffrey J. Hessekiel, J.D. | 2023 | 657,175 | — | 3,629,606 | — | 264,908 | 11,000 | 4,562,689 | ||
Executive Vice President, | 2022 | 630,285 | — | 3,656,426 | — | 318,399 | 11,000 | 4,616,110 | ||
General Counsel and Secretary | 2021 | 599,135 | — | 1,217,547 | — | 347,069 | 11,000 | 2,174,751 | ||
Amy C. Peterson, M.D. | 2023 | 201,846 | 265,530 | 5,220,000 | (8) | 1,590,000 | 90,470 | 11,000 | 7,378,846 | |
Executive Vice President, | ||||||||||
Product Development & Medical Affairs, and Chief Medical Officer | ||||||||||
Vicki L. Goodman, M.D. | 2023 | 456,025 | — | 3,759,230 | (9) | — | N/A | 768,425 | (10) | 4,983,680 |
Former Executive Vice President, | ||||||||||
2022 | 622,500 | 500,000 | 4,687,500 | (11) | — | 325,000 | 11,000 | 6,146,000 | ||
Product Development & Medical Affairs, and Chief Medical Officer |
Compensation of Executive Officers | Summary of Compensation |
2024 Proxy Statement | 75 |
Name | Payout of RSUs Granted in 2023 ($) | Target Payout of PSUs Granted in 2023 ($) | Maximum Payout of PSUs Granted in 2023 ($) |
Michael M. Morrissey, Ph.D. | 6,100,844 | 8,158,469 | 14,277,302 |
Christopher J. Senner | 1,663,865 | 2,225,035 | 3,893,811 |
Dana T. Aftab, Ph.D. | 2,990,088 | 1,780,023 | 3,115,033 |
Jeffrey J. Hessekiel, J.D. | 1,552,926 | 2,076,680 | 3,634,183 |
Amy C. Peterson, M.D. | 5,220,000 | — | — |
Vicki L. Goodman, M.D.* | 1,608,386 | 2,150,844 | 3,763,965 |
Compensation of Executive Officers | Summary of Compensation |
76 | Exelixis, Inc. |
Name | Payout of RSUs Granted in 2022 ($) | Target Payout of PSUs Granted in 2022 ($) | Maximum Payout of PSUs Granted in 2022 ($) |
Michael M. Morrissey, Ph.D. | 5,597,591 | 8,969,665 | 15,696,906 |
Christopher J. Senner | 1,572,890 | 2,520,422 | 4,410,714 |
Jeffrey J. Hessekiel, J.D. | 1,405,013 | 2,251,413 | 3,939,933 |
Vicki L. Goodman, M.D. | 4,687,500 | — | — |
Name | Threshold Payout of PSUs Granted in 2021 ($) | Target Payout of PSUs Granted in 2021 ($) | Maximum Payout of PSUs Granted in 2021 ($) |
Michael M. Morrissey, Ph.D. | 1,600,637 | 4,268,393 | 8,536,786 |
Christopher J. Senner | 512,633 | 1,367,037 | 2,734,073 |
Jeffrey J. Hessekiel, J.D. | 456,567 | 1,217,547 | 2,435,094 |
Compensation of Executive Officers | Summary of Compensation |
2024 Proxy Statement | 77 |
Estimated Future Payouts Under Non-Equity Incentive Plan Awards (1) | Estimated Future Payouts Under Equity Incentive Plan Awards (2) | All Other Stock Awards: Number of Shares of Stock or Units (#)(3) | All Other Option Awards: Number of Securities Underlying Options (#)(4) | Exercise or Base Price of Option Awards ($/Sh) | Grant Date Fair Value of Stock and Option Awards ($)(5) | ||||||||
Name | Grant Date | Threshold ($) | Target ($) | Maximum ($) | Threshold (#) | Target (#) | Maximum (#) | ||||||
Michael M. Morrissey, Ph.D. | |||||||||||||
4/3/2023 | — | — | — | — | — | — | 313,185 | — | 6,100,844 | ||||
4/3/2023 | — | — | — | 156,592 | 313,185 | 548,073 | — | — | 8,158,469 | ||||
N/A | — | 1,201,241 | 1,801,862 | — | — | — | — | — | |||||
Christopher J. Senner | |||||||||||||
4/3/2023 | — | — | — | — | — | — | 85,414 | — | 1,663,865 | ||||
4/3/2023 | — | — | — | 42,707 | 85,414 | 149,474 | — | — | 2,225,035 | ||||
N/A | — | 376,257 | 620,824 | — | — | — | — | — | |||||
Dana T. Aftab, Ph.D. | |||||||||||||
1/3/2023 | — | — | — | — | — | — | 100,000 | (6) | — | 1,659,000 | |||
4/3/2023 | — | — | — | — | — | — | 68,331 | — | 1,331,088 | ||||
4/3/2023 | — | — | — | 34,165 | 68,331 | 119,579 | — | — | 1,780,023 | ||||
N/A | — | 291,200 | 480,480 | — | — | — | — | — | |||||
Jeffrey J. Hessekiel, J.D. | |||||||||||||
4/3/2023 | — | — | — | — | — | — | 79,719 | — | 1,552,926 | ||||
4/3/2023 | — | — | — | 39,859 | 79,719 | 139,508 | — | — | 2,076,680 | ||||
N/A | — | 331,135 | 546,372 | — | — | — | — | — | |||||
Amy C. Peterson, M.D. | |||||||||||||
8/24/2023 | — | — | — | — | — | — | 240,000 | (7) | — | 5,220,000 | |||
8/24/2023 | — | — | — | — | — | — | — | 160,000 | 21.75 | 1,590,000 | |||
N/A | — | 106,667(8) | 176,000(8) | (8) | — | — | — | — | — | ||||
Vicki L. Goodman, M.D. (9) | — | — | — | — | — | — | — | ||||||
4/3/2023 | — | — | — | — | — | — | 82,566 | — | 1,608,386 | ||||
4/3/2023 | — | — | — | 41,283 | 82,566 | 144,490 | — | — | 2,150,844 | ||||
N/A | — | 325,000 | 536,250 | — | — | — | — | — |
Compensation of Executive Officers | Summary of Compensation |
78 | Exelixis, Inc. |
Compensation of Executive Officers | Grants of Plan-Based Awards |
2024 Proxy Statement | 79 |
80 | Exelixis, Inc. |
Option Awards(1) | Stock Awards(2) | ||||||||||||
Name | Grant Date | Number of Securities Underlying Unexercised Options (#) Exercisable | Number of Securities Underlying Unexercised Options (#) Unexercisable | Option Exercise Price ($) | Option Expiration Date | Number of Shares or Units of Stock That Have Not Vested (#) | Market Value of Shares or Units of Stock That Have Not Vested ($)(3) | Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) | Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($)(3) | ||||
Michael M. Morrissey, Ph.D. | 10/3/2017 | 480,000 | 24.41 | 10/2/2024 | |||||||||
9/10/2018 | 308,365 | 18.80 | 9/9/2025 | ||||||||||
10/22/2020 | 94,003 | (4) | 2,255,132 | 94,002 | (4) | 2,255,108 | |||||||
10/22/2020 | 94,003 | (5) | 2,255,132 | ||||||||||
3/4/2021 | 340,106 | 154,594 | (6) | 21.31 | 3/3/2028 | ||||||||
3/4/2021 | 250,374 | (7) | 6,006,472 | ||||||||||
3/4/2022 | 202,812 | 4,865,460 | |||||||||||
3/4/2022 | 270,415 | (8) | 6,487,256 | ||||||||||
4/3/2023 | 313,185 | 7,513,308 | |||||||||||
4/3/2023 | 313,185 | (9) | 7,513,308 | ||||||||||
Christopher J. Senner | 10/3/2017 | 125,000 | 24.41 | 10/2/2024 | |||||||||
9/10/2018 | 129,314 | 18.80 | 9/9/2025 | ||||||||||
9/11/2020 | 32,568 | (4) | 781,306 | 32,566 | (4) | 781,258 | |||||||
9/11/2020 | 32,568 | (5) | 781,306 | ||||||||||
3/4/2021 | 32,076 | 769,503 | |||||||||||
3/4/2021 | 80,186 | (7) | 1,923,662 | ||||||||||
3/4/2022 | 56,989 | 1,367,166 | |||||||||||
3/4/2022 | 75,985 | (8) | 1,822,880 | ||||||||||
4/3/2023 | 85,414 | 2,049,082 | |||||||||||
4/3/2023 | 85,414 | (9) | 2,049,082 | ||||||||||
Dana T. Aftab, Ph.D. | 10/3/2017 | 95,000 | 24.41 | 10/2/2024 | |||||||||
9/10/2018 | 96,986 | 18.80 | 9/9/2025 | ||||||||||
9/11/2020 | 25,330 | (4) | 607,667 | 25,330 | 607,667 | ||||||||
9/11/2020 | 25,330 | 607,667 | |||||||||||
3/4/2021 | 25,290 | 606,707 | |||||||||||
3/4/2021 | 63,224 | (7) | 1,516,744 | ||||||||||
3/4/2022 | 44,618 | 1,070,386 | |||||||||||
3/4/2022 | 59,490 | 1,427,165 | |||||||||||
1/5/2023 | 100,000 | (10) | 2,399,000 | ||||||||||
4/3/2023 | 68,331 | 1,639,261 | |||||||||||
4/3/2023 | 68,331 | (9) | 1,639,261 | ||||||||||
Compensation of Executive Officers | Outstanding Equity Awards at Fiscal Year-End |
2024 Proxy Statement | 81 |
Option Awards(1) | Stock Awards(2) | ||||||||||||
Name | Grant Date | Number of Securities Underlying Unexercised Options (#) Exercisable | Number of Securities Underlying Unexercised Options (#) Unexercisable | Option Exercise Price ($) | Option Expiration Date | Number of Shares or Units of Stock That Have Not Vested (#) | Market Value of Shares or Units of Stock That Have Not Vested ($)(3) | Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) | Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($)(3) | ||||
Jeffrey J. Hessekiel, J.D. | 10/3/2017 | 100,000 | 24.41 | 10/2/2024 | |||||||||
9/10/2018 | 129,314 | 18.80 | 9/9/2025 | ||||||||||
9/11/2020 | 28,950 | (4) | 694,511 | 28,950 | (4) | 694,511 | |||||||
9/11/2020 | 28,950 | (5) | 694,511 | ||||||||||
3/4/2021 | 28,568 | 685,346 | |||||||||||
3/4/2021 | 71,418 | (7) | 1,713,318 | ||||||||||
3/4/2022 | 50,907 | 1,221,259 | |||||||||||
3/4/2022 | 67,875 | (8) | 1,628,321 | ||||||||||
4/3/2023 | 79,719 | 1,912,459 | |||||||||||
4/3/2023 | 79,719 | (9) | 1,912,459 | ||||||||||
Amy C. Peterson, M.D. | 8/24/2023 | 160,000 | (11) | 21.75 | 8/23/2030 | ||||||||
8/24/2023 | 240,000 | (12) | 5,757,600 |
82 | Exelixis, Inc. |
Compensation of Executive Officers | Outstanding Equity Awards at Fiscal Year-End |
2024 Proxy Statement | 83 |
Option Awards | Stock Awards | ||||
Name | Number of Shares Acquired on Exercise (#) | Value Realized on Exercise ($)(1) | Number of Shares Acquired on Vesting (#) | Value Realized on Vesting ($)(2) | |
Michael M. Morrissey, Ph.D. | 460,000 | 3,789,200 | 231,845 | 4,821,203 | |
Christopher J. Senner | 120,000 | 702,511 | 93,630 | 1,923,677 | |
Dana T. Aftab, Ph.D. | 82,500 | 227,702 | 69,260 | 1,432,063 | |
Jeffrey J. Hessekiel, J.D. | 97,500 | 412,508 | 79,674 | 1,645,833 | |
Amy C. Peterson, M.D. | — | — | — | — | |
Vicki L. Goodman, M.D. | — | — | 59,868 | 1,082,413 |
84 | Exelixis, Inc. |
Compensation of Executive Officers | Potential Payments Upon Termination or Change in Control |
2024 Proxy Statement | 85 |
Change in Control and Severance Benefit Plan | Equity Plans | ||||
Name | Benefit | Change in Control Termination ($)(1) | Non-Change in Control Termination ($)(2) | Certain Change in Control Transactions without Termination ($)(3) | |
Michael M. Morrissey, Ph.D. | Base Salary | 2,402,482 | 1,801,862 | — | |
Bonus | 2,402,482 | 960,993 | — | ||
Vesting Acceleration (4) | 36,109,081 | — | 36,109,081 | ||
COBRA Payments | 60,230 | 45,172 | — | ||
Outplacement Services | 50,000 | — | — | ||
Benefit Total | 41,024,275 | 2,808,027 | 36,109,081 | ||
Christopher J. Senner | Base Salary | 1,128,771 | 752,514 | — | |
Bonus | 564,386 | 301,006 | — | ||
Vesting Acceleration (4) | 11,159,284 | — | 11,159,284 | ||
COBRA Payments | 68,930 | 45,953 | — | ||
Outplacement Services | 30,000 | — | — | ||
Benefit Total | 12,951,371 | 1,099,473 | 11,159,284 | ||
86 | Exelixis, Inc. |
Change in Control and Severance Benefit Plan | Equity Plans | ||||
Name | Benefit | Change in Control Termination ($)(1) | Non-Change in Control Termination ($)(2) | Certain Change in Control Transactions without Termination ($)(3) | |
Dana T. Aftab, Ph.D. | Base Salary | 873,600 | 582,400 | — | |
Bonus | 436,800 | 232,960 | — | ||
Vesting Acceleration (4) | 11,210,527 | — | 11,210,527 | ||
COBRA Payments | 53,308 | 35,539 | — | ||
Outplacement Services | 30,000 | — | — | ||
Benefit Total | 12,604,235 | 850,899 | 11,210,527 | ||
Jeffrey J. Hessekiel, J.D. | Base Salary | 993,403 | 662,269 | — | |
Bonus | 496,702 | 264,908 | — | ||
Vesting Acceleration (4) | 10,119,534 | — | 10,119,534 | ||
COBRA Payments | 68,930 | 45,953 | — | ||
Outplacement Services | 30,000 | — | — | ||
Benefit Total | 11,708,569 | 973,130 | 10,119,534 | ||
Amy C. Peterson, M.D. | Base Salary | 960,000 | 640,000 | — | |
Bonus | 480,000 | 85,333 | (5) | — | |
Vesting Acceleration (4) | 6,116,000 | — | 6,116,000 | ||
COBRA Payments | 68,930 | 45,953 | — | ||
Outplacement Services | 30,000 | — | — | ||
Benefit Total | 7,654,930 | 771,286 | 6,116,000 | ||
Vicki L. Goodman, M.D. (6) | Base Salary | — | 672,750 | — | |
Bonus | — | — | — | ||
Vesting Acceleration (4) | — | — | — | ||
COBRA Payments | — | 4,675 | — | ||
Outplacement Services | — | — | — | ||
Benefit Total | — | 677,425 | — |
Compensation of Executive Officers | Potential Payments Upon Termination or Change in Control |
2024 Proxy Statement | 87 |
Name | Vesting Acceleration Benefit for Outstanding PSUs Granted in 2020 ($) | Vesting Acceleration Benefit for Outstanding PSUs Granted in 2021 ($) | Vesting Acceleration Benefit for Outstanding PSUs Granted in 2022 ($) |
Michael M. Morrissey, Ph.D. | 1,691,343 | 3,203,457 | 2,162,411 |
Christopher J. Senner | 585,980 | 1,025,956 | 607,619 |
Dana T. Aftab, Ph.D. | 455,738 | 808,943 | 475,722 |
Jeffrey J. Hessekiel, J.D. | 520,871 | 913,779 | 542,774 |
Amy C. Peterson, M.D. | — | — | — |
Vicki L. Goodman, M.D. | — | — | — |
88 | Exelixis, Inc. |
Compensation of Executive Officers | Pay Versus Performance |
2024 Proxy Statement | 89 |
Value of Initial Fixed $100 Investment Based On: | Net Income (millions) ($) | Net Product Revenues (millions) ($)(5) | ||||||
Year | Summary Compensation Table Total for PEO ($)(1) | Compensation Actually Paid to PEO ($)(1)(2) | Average Summary Compensation Table Total for Non-PEO NEOs ($)(1) | Average Compensation Actually Paid to Non-PEO NEOs ($)(1)(2) | Total Stockholder Return ($)(3) | Peer Group Total Stockholder Return ($)(4) | ||
2023 | ||||||||
2022 | ||||||||
2021 | ||||||||
2020 |
Year | Summary Compensation Table Total for PEO ($) | Exclusion of Stock Awards and Options Awards for PEO ($) | Inclusion of Equity Values for PEO ($) | Compensation Actually Paid to PEO ($) |
2023 | ( |
Year | Average Summary Compensation Table Total for Non-PEO NEOs ($) | Average Exclusion of Stock Awards and Options Awards for Non-PEO NEOs ($) | Average Inclusion of Equity Values for Non-PEO NEOs ($) | Average Compensation Actually Paid to Non-PEO NEOs ($) |
2023 | ( |
Year | Year End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for PEO ($) | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years for PEO ($) | Fair Value as of Vesting Date of Equity Awards Granted and Vested During Year for PEO ($) | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested During Year for PEO ($) | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($) | Total – Inclusion of Equity Values for PEO ($) |
2023 |
90 | Exelixis, Inc. |
Year | Average Year End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Non-PEO NEOs ($) | Average Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years for Non- PEO NEOs ($) | Average Fair Value as of Vesting Date of Equity Awards Granted and Vested During Year for Non-PEO NEOs ($) | Average Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested During Year for Non-PEO NEOs ($) | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) | Total – Average Inclusion of Equity Values for Non-PEO NEOs ($) | |
2023 | ( |
Compensation of Executive Officers | Pay Versus Performance |
2024 Proxy Statement | 91 |
Compensation of Executive Officers | Pay Versus Performance |
2024 Proxy Statement | 93 |
94 | Exelixis, Inc. |
By Order of the Board of Directors | |
JEFFREY J. HESSEKIEL | |
Executive Vice President, General Counsel and Secretary | |
Alameda, California | |
April 18, 2024 |
Householding of Proxy Materials |
2024 Proxy Statement | 95 |