AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 28, 2003
                                                           REGISTRATION NO. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                                 EXELIXIS, INC.
             (Exact name of registrant as specified in its charter)

                Delaware                       04-3257395
     (State or other jurisdiction of        (I.R.S.  Employer
     incorporation  or  organization)     Identification  Number)

                                 170 Harbor Way
                                  P.O. Box 511
                          South San Francisco, CA 94083
                                 (650) 837-7000
                    (Address of principal executive offices)

                           2000 EQUITY INCENTIVE PLAN
                        2000 EMPLOYEE STOCK PURCHASE PLAN
                 2000 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN
                            (Full title of the plans)

                                  Glen Y. Sato
                             Chief Financial Officer
                                 Exelixis, Inc.
                                 170 Harbor Way
                                  P.O. Box 511
                          South San Francisco, CA 94083
                                 (650) 837-7000
(Name, address, including zip code, and telephone number, including area code,of
                               agent for service)

                                   Copies to:
                              ROBERT L. JONES, ESQ.
                               COOLEY GODWARD LLP
                              FIVE PALO ALTO SQUARE
                               3000 EL CAMINO REAL
                           PALO ALTO, CALIFORNIA 94306

CALCULATION OF REGISTRATION FEE ======================================================================================================================= PROPOSED MAXIMUM TITLE OF CLASS OF SECURITIES AMOUNT TO BE PROPOSED MAXIMUM OFFERING AGGREGATE OFFERING AMOUNT OF TO BE REGISTERED REGISTERED(1) PRICE PER SHARE (2) PRICE (2) REGISTRATION FEE - ------------------------------ ----------------- --------------------------- -------------------- ----------------- - ------------------------------ ----------------- --------------------------- -------------------- ----------------- Stock Options and Common Stock 4,853,009 shares $ 6.96 $ 33,776,924.64 $ 3,107.48 (par value $.001) =======================================================================================================================
(1) This Registration Statement shall cover any additional shares of common stock that become issuable under the 2000 Equity Incentive Plan, 2000 Non-Employee Directors' Stock Option Plan and 2000 Employee Stock Purchase Plan set forth herein by reason of any stock dividend, stock split, recapitalization or any other similar transaction without receipt of consideration which results in an increase in the number of shares of the Registrant's outstanding common stock. (2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and (h)(1) under the Securities Act of 1933, as amended (the "Act"). The offering price per share and aggregate offering price for the unissued stock options and common stock are based upon the average of the high and low prices of the Registrant's common stock as reported on the Nasdaq National Market System on January 27, 2003. The following chart illustrates the calculation of the registration fee:
TITLE OF SHARES NUMBER OF SHARES OFFERING PRICE PER AGGREGATE OFFERING SHARE PRICE Shares issuable pursuant to unissued stock options 3,849,981 $ 6.96 $ 26,795,867.76 pursuant to the 2000 Equity Incentive Plan Shares issuable pursuant to unissued stock options 501,514 $ 6.96 $ 3,490,537.44 pursuant to the 2000 Non-Employee Directors' Stock Option Plan Shares issuable pursuant to the 2000 Employee Stock Purchase Plan 501,514 $ 6.96 $ 3,490,537.44 Proposed Maximum Aggregate Offering Price $ 33,776,924.64
Approximate date of commencement of proposed sale to the public: as soon as practicable after this Registration Statement becomes effective. EXPLANATORY NOTE This Registration Statement on Form S-8 is being filed for the purpose of registering an additional: (i) 3,849,981 shares of the Registrant's common stock to be issued pursuant to the Registrant's 2000 Equity Incentive Plan; (ii) 501,514 shares of the Registrant's common stock to be issued pursuant to the Registrant's 2000 Non-Employee Directors' Stock Option Plan; and (iii) 501,514 shares of the Registrant's common stock to be issued pursuant to the Registrant's 2000 Employee Stock Purchase Plan. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE The contents of the Registration Statements on Form S-8 (relating to the 2000 Equity Incentive Plan, 2000 Non-Employee Directors' Stock Option Plan and 2000 Employee Stock Purchase Plan) File Nos. 333-35862, 333-57026 and 333-82722 previously filed with the SEC on April 28, 2000, March 14, 2001 and February 14, 2002, respectively, are incorporated by reference herein. ITEM 8. EXHIBITS EXHIBIT NUMBER DESCRIPTION 4.1* Amended and Restated Certificate of Incorporation of the Company. 4.2* Restated Bylaws of the Company. 5.1 Opinion of Cooley Godward llp. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 23.2 Consent of Independent Accountants. 23.3 Consent of Cooley Godward llp is contained in Exhibit 5.1 to this Registration Statement. 24.1 Power of Attorney is contained on the signature pages to this Registration Statement. 99.1* 2000 Equity Incentive Plan. 99.2* 2000 Employee Stock Purchase Plan. 99.3* 2000 Non-Employee Directors' Stock Option Plan. 99.4 Selected Financial Data Additional Disclosure for FASB No. 142. ________________________ *Incorporated by reference to the Company's Registration Statement on Form S-1, as amended (File No.333-96335), originally filed with the SEC on February 7, 2000. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on January 28, 2003. EXELIXIS, INC. By: /s/ George A. Scangos ------------------------- George A. Scangos, Ph.D. President and Chief Executive Officer POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints George A. Scangos and Glen Y. Sato, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
SIGNATURE TITLE DATE - ------------------------------ ---------------------------------- ------------------ /s/ George A. Scangos President, Chief Executive January 28, 2003 - ------------------------------ Officer and Director George A. Scangos, Ph.D. (Principal Executive Officer) /s/ Glen Y. Sato Chief Financial Officer January 28, 2003 - ------------------------------ (Principal Financial and Glen Y. Sato Accounting Officer) /s/ Stelios Papadopoulos Chairman of the Board of - ------------------------------- Directors January 28, 2003 Stelios Papadopoulos, Ph.D. /s/ Charles Cohen - ------------------------------ Director January 28, 2003 Charles Cohen, Ph.D. /s/ Geoffrey Duyk Director January 28, 2003 - ------------------------------- Geoffrey Duyk, M.D., Ph.D. /s/ Jason Fisherman Director January 28, 2003 - ------------------------------- Jason S. Fisherman, M.D. /s/ Jean-Francois Formela Director January 28, 2003 - ------------------------------- Jean-Francois Formela, M.D. /s/ Vincent T. Marchesi Director January 28, 2003 - ------------------------------- Vincent T. Marchesi, Ph.D. /s/ Peter Stadler Director January 28, 2003 - ------------------------------- Peter Stadler, Ph.D. /s/ Lance Willsey ------------------------------ Director January 28, 2003 Lance Willsey, M.D.
EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION 4.1* Amended and Restated Certificate of Incorporation of the Company. 4.2* Restated Bylaws of the Company. 5.1 Opinion of Cooley Godward llp. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 23.2 Consent of Independent Accountants. 23.3 Consent of Cooley Godward llp is contained in Exhibit 5.1 to this Registration Statement. 24.1 Power of Attorney is contained on the signature pages to this Registration Statement. 99.1* 2000 Equity Incentive Plan. 99.2* 2000 Employee Stock Purchase Plan. 99.3* 2000 Non-Employee Directors' Stock Option Plan. 99.4 Selected Financial Data Additional Disclosure for FASB No. 142. ________________________ *Incorporated by reference to the Company's Registration Statement on Form S-1, as amended (File No.333-96335), originally filed with the SEC on February 7, 2000.
                                                                     EXHIBIT 5.1


                                                           Robert L. Jones, Esq.
                                                          Direct: (650) 843-5034
                                                    Internet: jonesrl@cooley.com


January  28,  2003



Exelixis,  Inc.
170  Harbor  Way
P.O.  Box  511
South  San  Francisco,  CA  94083


Ladies  and  Gentlemen:

You  have  requested  our  opinion with respect to certain matters in connection
with the filing by Exelixis, Inc. (the "Company") of a Registration Statement on
Form  S-8  (the  "Registration  Statement")  with  the  Securities  and Exchange
Commission  covering  the  offering  of  an aggregate of 4,853,009 shares of the
Company's  common  stock,  $.001  par  value  (the  "Shares"),  pursuant  to the
Company's  2000 Equity Incentive Plan, 2000 Non-Employee Directors' Stock Option
Plan  and  2000  Employee  Stock  Purchase  Plan  (collectively  the  "Plans").

In connection with this opinion, we have examined the Registration Statement and
related  Prospectus,  your Amended and Restated Certificate of Incorporation and
Restated  Bylaws  and such other documents, records, certificates, memoranda and
other  instruments  as  we  deem  necessary as a basis for this opinion. We have
assumed  the  genuineness  and  authenticity of all documents submitted to us as
originals,  the  conformity  to  originals  of  all documents submitted to us as
copies  thereof  and  the  due execution and delivery of all documents where due
execution  and  delivery  are  a  prerequisite  to  the  effectiveness  thereof.

On  the  basis  of the foregoing, and in reliance thereon, we are of the opinion
that  the  Shares,  when  sold  and  issued  in  accordance  with the Plans, the
Registration Statement and the related Prospectus, will be validly issued, fully
paid  and nonassessable (except as to shares issued pursuant to certain deferred
payment  arrangements,  which  will  be  fully  paid and nonassessable when such
deferred  payments  are  made  in  full).

We  consent  to  the  filing  of  this opinion as an exhibit to the Registration
Statement.

Very  truly  yours,

Cooley  Godward  llp



By:     /s/  Robert  L.  Jones
        ----------------------
             Robert  L.  Jones



                                                                    EXHIBIT 23.1

                CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in the Registration Statement (Form
S-8)  pertaining  to  the  2000  Equity  Incentive Plan, the 2000 Employee Stock
Purchase  Plan,  and  the  2000  Non-Employee  Directors'  Stock  Option Plan of
Exelixis,  Inc.  of  our  report  dated  February  1,  2002, with respect to the
consolidated  financial  statements  of  Exelixis,  Inc.  included in its Annual
Report  (Form  10-K)  for  the  year  ended  December  31,  2001, filed with the
Securities  and  Exchange  Commission.

/s/  Ernst  &  Young  LLP

Palo  Alto,  California
January  27,  2003





                                                                    EXHIBIT 23.2

                       CONSENT OF INDEPENDENT ACCOUNTANTS

We  hereby  consent  to  the  incorporation  by  reference  in this Registration
Statement  on  Form  S-8  of  our  report dated February 2, 2001 relating to the
consolidated  balance  sheet  as  of  December  31,  2000  and  the consolidated
statements  of operations, of stockholders' equity and of cash flows for each of
the  two years in the period ended December 31, 2000, which appears in Exelixis,
Inc.'s  Annual  Report  on  Form  10-K  for  the  year  ended December 31, 2001.

/s/  PricewaterhouseCoopers  LLP

San  Jose,  California
January  27,  2003





                                                                    EXHIBIT 23.2

    SELECTED FINANCIAL DATA ADDITIONAL DISCLOSURE FOR FASB NO. 142, "GOODWILL
                          AND OTHER INTANGIBLE ASSETS"

On  January  1,  2002,  the  Company  adopted  Statement of Financial Accounting
Standards ("SFAS") No. 142, "Goodwill and Other Intangible Assets" ("SFAS 142"),
which  addresses  the  financial accounting and reporting standards for goodwill
and  other  intangible  assets  subsequent to their acquisition. This accounting
standard  requires  that goodwill no longer be amortized, and instead, be tested
for  impairment  on  a  periodic  basis.

In  accordance  with  SFAS  142,  the  Company  discontinued the amortization of
goodwill  effective  January  1, 2002. In addition, the Company re-characterized
acquired  assembled  workforce as goodwill because it is no longer defined as an
acquired  intangible  asset  under  SFAS  No.  141, "Business Combinations". The
provisions  of SFAS 142 also require the completion of a transitional impairment
test within nine months of adoption, with any impairment treated as a cumulative
effect  of change in accounting principle. During the first quarter of 2002, the
Company  completed  the  transitional  impairment  test, which did not result in
impairment  of  recorded goodwill. In addition, the Company completed its annual
impairment  test  on  October  1,  2002,  which  did not result in impairment of
recorded  goodwill.  The  Company will continue to monitor the carrying value of
goodwill  through  annual  impairment  tests.

A  reconciliation  of previously reported net loss and net loss per share to the
amounts  adjusted  for  the  exclusion  of  goodwill  and  assembled  workforce
amortization  follows  (in  thousands,  except  per  share  amounts):
FISCAL YEAR ENDED DECEMBER 31, ------------------------------ 2001 2000 1999 --------- --------- --------- Reported net loss. . . . . . . . . . . . . . . $(71,186) $(75,311) $(18,721) Add: Goodwill amortization . . . . . . . . . . 4,052 219 - Assembled workforce amortization . . 593 20 - --------- --------- --------- Adjusted net loss. . . . . . . . . . . . . . . $(66,541) $(75,072) $(18,721) ========= ========= ========= Net loss per share, basic and diluted. . . . . $ (1.53) $ (2.43) $ (4.60) Add: Goodwill amortization . . . . . . . . . . 0.09 0.01 - Assembled workforce amortization . . 0.01 0.00 - --------- --------- --------- Adjusted net loss per share, basic and diluted $ (1.43) $ (2.42) $ (4.60) ========= ========= =========