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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1 )*

                                 EXELIXIS, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                          COMMON STOCK, $.001 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    30161Q104
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [_] Rule 13d-1(b)

     [_] Rule 13d-1(c)

     [X] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).




CUSIP No. 30161Q104                                             Page 2 of 19

- -------------------------------------------------------------------------------
  1    NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

       Atlas Venture Fund II, L.P.
- -------------------------------------------------------------------------------
  2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                                  (a) [_]
                                                                  (b) [_]
- -------------------------------------------------------------------------------
  3    SEC USE ONLY


- -------------------------------------------------------------------------------
  4    CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware Limited Partnership
- -------------------------------------------------------------------------------
                           5   SOLE VOTING POWER

       NUMBER OF               0 shares
                          -----------------------------------------------------
         SHARES            6   SHARED VOTING POWER
      BENEFICIALLY
        OWNED BY               3,484,919 shares
                          -----------------------------------------------------
          EACH             7   SOLE DISPOSITIVE POWER
       REPORTING
         PERSON                0 shares
                          -----------------------------------------------------
         WITH:             8   SHARED DISPOSITIVE POWER

                               3,484,919 shares
- -------------------------------------------------------------------------------
  9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       3,484,919 shares
- -------------------------------------------------------------------------------
10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
       (SEE INSTRUCTIONS)
                                                                      [_]
- -------------------------------------------------------------------------------
11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

       7.0%
- -------------------------------------------------------------------------------
12     TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

       IN
- -------------------------------------------------------------------------------




CUSIP No. 30161Q104                                             Page 3 of 19

- -------------------------------------------------------------------------------
  1    NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

       Atlas Venture Associates II, L.P.
- -------------------------------------------------------------------------------
  2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                                  (a) [_]
                                                                  (b) [_]
- -------------------------------------------------------------------------------
  3    SEC USE ONLY


- -------------------------------------------------------------------------------
  4    CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware Limited Partnership
- -------------------------------------------------------------------------------
                           5   SOLE VOTING POWER

       NUMBER OF               0 shares
                          -----------------------------------------------------
         SHARES            6   SHARED VOTING POWER
      BENEFICIALLY
        OWNED BY               3,484,919 shares
                          -----------------------------------------------------
          EACH             7   SOLE DISPOSITIVE POWER
       REPORTING
         PERSON                0 shares
                          -----------------------------------------------------
         WITH:             8   SHARED DISPOSITIVE POWER

                               3,484,919 shares
- -------------------------------------------------------------------------------
  9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       3,484,919 shares
- -------------------------------------------------------------------------------
10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
       (SEE INSTRUCTIONS)
                                                                      [_]
- -------------------------------------------------------------------------------
11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

       7.0%
- -------------------------------------------------------------------------------
12     TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

       IN
- -------------------------------------------------------------------------------






CUSIP No. 30161Q104                                             Page 4 of 19

- -------------------------------------------------------------------------------
  1    NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

       Christopher J. Spray
- -------------------------------------------------------------------------------
  2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                                  (a) [_]
                                                                  (b) [_]

- -------------------------------------------------------------------------------
  3    SEC USE ONLY


- -------------------------------------------------------------------------------
  4    CITIZENSHIP OR PLACE OF ORGANIZATION

       United Kingdom
- -------------------------------------------------------------------------------
                           5   SOLE VOTING POWER

       NUMBER OF               0 shares
                          -----------------------------------------------------
         SHARES            6   SHARED VOTING POWER
      BENEFICIALLY
        OWNED BY               2,325,398 shares
                          -----------------------------------------------------
          EACH             7   SOLE DISPOSITIVE POWER
       REPORTING
         PERSON                0 shares
                          -----------------------------------------------------
         WITH:             8   SHARED DISPOSITIVE POWER

                               2,325,398 shares
- -------------------------------------------------------------------------------
  9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       2,325,398 shares
- -------------------------------------------------------------------------------
10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
       (SEE INSTRUCTIONS)
                                                                      [_]
- -------------------------------------------------------------------------------
11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

       4.7%
- -------------------------------------------------------------------------------
12     TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

       IN
- -------------------------------------------------------------------------------



CUSIP No. 30161Q104                                              Page 5 of 19


- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS
 1    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Barry Fidelman
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      United States
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0 shares
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
     OWNED BY             2,325,398 shares
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0 shares
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          2,325,398 shares
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      2,325,398 shares
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11
      4.7%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12
      IN
- ------------------------------------------------------------------------------



  CUSIP NO. 30161Q104                                             Page 6 of 19

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS
 1    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Jean-Francois Formela
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      France
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            36,708 shares
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
     OWNED BY             2,325,398 shares
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             36,708 shares
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH:         8
                          2,325,398 shares
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      2,362,106 shares
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      4.8%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12
      IN
- ------------------------------------------------------------------------------



  CUSIP NO. 30161Q104                                           Page 7 of 19

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS
 1    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Atlas Venture Europe Fund B.V.
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      The Netherlands
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0 shares
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
     OWNED BY             3,484,919 shares
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0 shares
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH:         8
                          3,484,919 shares
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      3,484,919 shares
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11
      7.0%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12
      CO
- ------------------------------------------------------------------------------



                                                                 Page 8 of 19
 CUSIP No. 30161Q104

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS
 1    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Atlas InvesteringsGroep N.V.
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3

- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      The Netherlands
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0 shares
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
     OWNED BY             3,484,919 shares
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0 shares
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH:         8
                          3,484,919 shares
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      3,484,919 shares
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      7.0%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12
      CO
- ------------------------------------------------------------------------------




                                  Schedule 13G
                                  ------------

Item 1(a).        Name of Issuer:  Exelixis, Inc.
                  --------------

Item 1(b).        Address of Issuer's Principal Executive Offices:
                  -----------------------------------------------
                  170 Harbor Way, P.O. Box 511, South San Francisco, CA 94083.

Item 2(a).        Names of Persons Filing:  Atlas Venture Fund II, L.P., Atlas
                  -----------------------
                  Venture Associates II, L.P., Christopher J. Spray, Barry
                  Fidelman, Jean-Francois Formela, Atlas Venture Europe Fund
                  B.V. and Atlas InvesteringsGroep N.V.

                  Atlas Venture Associates II, L.P. is the sole general partner
                  of Atlas Venture Fund II, L.P. Messrs. Spray, Fidelman and
                  Formela are the individual general partners of Atlas Venture
                  Associates II, L.P. Atlas InvesteringsGroep N.V. is the owner
                  of 95% of the shares of Atlas Venture Europe Fund B.V.

Item 2(b).        Address of Principal Business Office or, if None, Residence:
                  -----------------------------------------------------------
                  The address of the principal business office of Atlas Venture
                  Fund II, L.P., Atlas Venture Associates II, L.P. and Messrs.
                  Spray, Fidelman and Formela is Atlas Venture, 222 Berkeley
                  Street, Boston, Massachusetts 02116. The address of the
                  principal business office of Atlas Venture Europe Fund B.V.
                  and Atlas InvesteringsGroep N.V. is Atlas InvesteringsGroep
                  N.V., Leevwenveldesweg 16, 1382 LX Weesp, The Netherlands.

Item 2(c).        Citizenship:  Atlas Venture Fund II, L.P. and Atlas Venture
                  -----------
                  Associates II, L.P. are each a limited partnership organized
                  under the laws of the State of Delaware. Mr. Fidelman is a
                  citizen of the United States. Mr. Spray is a citizen of the
                  United Kingdom. Mr. Formela is a citizen of France. Atlas
                  Venture Europe Fund B.V. and Atlas InvesteringsGroep N.V. are
                  each a corporation organized under the laws of The
                  Netherlands.

Item 2(d).        Title of Class of Securities:  Common Stock, $.001 par value.
                  ----------------------------

Item 2(e).        CUSIP Number:  30161Q104.
                  ------------

Item 3.           If this statement is filed pursuant to Rules 13d-1(b), or
                  ---------------------------------------------------------
                  13d-2(b) or (c), check whether the person filing is a:
                  -----------------------------------------------------

                  Not Applicable.

Item 4.           Ownership.
                  ---------

         (a)      Amount Beneficially Owned:

                  Each of Atlas Venture Fund II, L.P., Atlas Venture Associates
                  II, L.P., Atlas Venture Europe Fund B.V. and Atlas
                  InvesteringsGroep N.V. (individually an "Entity" and
                  collectively the "Entities") may be deemed to own beneficially
                  3,484,919 shares of Common Stock as of December 31, 2001. Each
                  of Messrs. Spray and Fidelman may be deemed to own
                  beneficially 2,325,398 shares of

                                  Page 9 of 19



                  Common Stock as of December 31, 2001. Mr. Formela may be
                  deemed to own beneficially 2,362,106 shares (including 16,500
                  shares and options exercisable for 20,208 shares) of Common
                  Stock as of December 31, 2001.

                  As of December 31, 2001, Atlas Venture Fund II, L.P. is the
                  record owner of 2,325,398 shares of Common Stock and Atlas
                  Venture Europe Fund B.V. is the record owner of 1,159,521
                  shares of Common Stock (referred to as the "Record Shares").
                  By virtue of the affiliate relationships among the Entities,
                  each Entity may be deemed to own beneficially all of the
                  Record Shares. Hence, each Entity may be deemed to own
                  beneficially 3,484,919 shares of Common Stock. In their
                  capacities as individual general partners of Atlas Venture
                  Associates II, L.P., each of Messrs. Spray and Fidelman may be
                  deemed to own beneficially 2,325,398 shares of Common Stock.
                  Mr. Formela may be deemed to own beneficially 2,362,106 shares
                  (including 16,500 shares and options exercisable for 20,208
                  shares) of Common Stock.

         (b)      Percent of Class:

                  Atlas Venture Fund II, L.P.           7.0%
                  Atlas Venture Associates II, L.P.     7.0%
                  Christopher J. Spray                  4.7%
                  Barry Fidelman                        4.7%
                  Jean-Francois Formela                 4.8%
                  Atlas Venture Europe Fund B.V.        7.0%
                  Atlas InvesteringsGroep N.V.          7.0%

         The foregoing percentages are calculated based on the 49,511,273 shares
         of Common Stock reported to be outstanding in a Quarterly Report on
         Form 10-Q for Exelixis, Inc. for the Quarter Ended September 30, 2001,
         as adjusted pursuant to Rule 13d-3(d)(1).

         (c)      Number of shares as to which such person has:

                  (i)     sole power to vote or to direct the vote:


                           Jean-Francois Formela                  36,708 shares

                          0 shares as to each other reporting person.

                  (ii)    shared power to vote or to direct the vote:

                          Atlas Venture Fund II, L.P.          3,484,919 shares
                          Atlas Venture Associates II, L.P.    3,484,919 shares
                          Christopher J. Spray                 2,325,398 shares
                          Barry Fidelman                       2,325,398 shares
                          Jean-Francois Formela                2,325,398 shares
                          Atlas Venture Europe Fund B.V.       3,484,919 shares
                          Atlas InvesteringsGroep N.V.         3,484,919 shares

                  (iii)   sole power to dispose or to direct the disposition of:

Page 10 of 19


                           Jean-Francois Formela                   36,708 shares

                          0 shares as to each other reporting person.

                  (iv)    shared power to dispose or to direct the disposition
                          of:

                          Atlas Venture Fund II, L.P.           3,484,919 shares
                          Atlas Venture Associates II, L.P.     3,484,919 shares
                          Christopher J. Spray                  2,325,398 shares
                          Barry Fidelman                        2,325,398 shares
                          Jean-Francois Formela                 2,325,398 shares
                          Atlas Venture Europe Fund B.V.        3,484,919 shares
                          Atlas InvesteringsGroep N.V.          3,484,919 shares

         Each of the reporting persons expressly disclaims beneficial ownership
         of any shares of Common Stock of Exelixis, Inc., except in the case of
         (i) Atlas Venture Fund II, L.P. for the 2,325,398 shares which it holds
         of record; (ii) Atlas Venture Europe Fund B.V. for the 1,159,521 shares
         which it holds of record and (iii) Jean-Francois Formela for the 36,708
         shares which he holds of record.

Item 5.           Ownership of Five Percent or Less of a Class.
                  --------------------------------------------

                  [x] In their capacities as individual general partners of
                  Atlas Venture Associates II, L.P., each of Messrs. Spray and
                  Fidelman may be deemed to own beneficially 2,325,398 shares of
                  Common Stock as of December 31, 2001, which is five percent or
                  less of the Common Stock of Exelixis, Inc.

                  In his capacity as individual general partner of Atlas Venture
                  Associates II, L.P., Mr. Formela may be deemed to own
                  beneficially 2,362,106 shares of Common Stock as of December
                  31, 2001 (including 36,708 shares which he holds of record),
                  which is five percent or less of the Common Stock of Exelixis,
                  Inc.

Item 6.           Ownership of More than Five Percent on Behalf of Another
                  --------------------------------------------------------
                  Person.
                  ------

                  Not Applicable.


Item 7.           Identification and Classification of the Subsidiary Which
                  ---------------------------------------------------------
                  Acquired the Security Being Reported on by the Parent Holding
                  -------------------------------------------------------------
                  Company.
                  -------

                  Not Applicable.

Item 8.           Identification and Classification of Members of the Group.
                  ---------------------------------------------------------

                  Not Applicable. The reporting persons expressly disclaim
                  membership in a "group" as defined in Rule 13d-1(b)(1)(ii)(J).

Item 9.           Notice of Dissolution of Group.
                  ------------------------------

Page 11 of 19






                  Not Applicable.

Item 10.          Certifications.
                  --------------

                  Not Applicable. This statement on Schedule 13G is not filed
                  pursuant to Rule 13d-1(b) or Rule 13d-1(c).

Page 12 of 19





                                   Signatures
                                   ----------

         After reasonable inquiry and to the best of our knowledge and belief,
we certify that the information set forth in this statement is true, complete
and correct. We also hereby agree to file this statement jointly pursuant to the
Agreement listed on Exhibit 1 hereto.
                    ---------

Dated:  February 8, 2002

ATLAS VENTURE FUND II, L.P.                     ATLAS VENTURE EUROPE FUND B.V.

By: Atlas Venture Associates II, L.P.           By: Atlas InvesteringsGroep N.V.

         By:                 *                        By:         *
            ------------------------------               -----------------------
              Christopher J. Spray,                      Hans Bosman,
              General Partner                            Managing Director

ATLAS VENTURE ASSOCIATES II, L.P.               ATLAS INVESTERINGSGROEP N.V.

By:                          *                  By:               *
    --------------------------------------         -----------------------------
     Christopher J. Spray,                         Hans Bosman,
     General Partner                               Managing Director


                             *
- ------------------------------------------
Christopher J. Spray

                             *
- ------------------------------------------
Barry Fidelman

                             *
- ------------------------------------------
Jean-Francois Formela

*   The undersigned attorney-in-fact, by signing her name below, does hereby
    sign this statement on behalf of the above indicated filers pursuant to
    Powers of Attorney filed hereto as Exhibit 2.
                                       ---------

     /s/Jeanne Larkin Henry
     ----------------------
     Jeanne Larkin Henry
     Attorney-in-fact

                                 Page 13 of 19



                                                                       Exhibit 1
                                                                       ---------

                                    AGREEMENT

         Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934,
the undersigned hereby agree that only one statement containing the information
required by Schedule 13G need be filed with respect to the ownership by each of
the undersigned of shares of Common Stock of Exelixis, Inc.

         This agreement may be executed in any number of counterparts, each of
which shall be deemed an original.

         EXECUTED this 8th day of February, 2002.

ATLAS VENTURE FUND II, L.P.               ATLAS VENTURE EUROPE FUND B.V.

By: Atlas Venture Associates II, L.P.     By: Atlas InvesteringsGroep N.V.

         By:       *                             By:          *
            ---------------------------             ----------------------------
            Christopher J. Spray,                   Hans Bosman,
            General Partner                         Managing Director

ATLAS VENTURE ASSOCIATES II, L.P.         ATLAS INVESTERINGSGROEP N.V.

By:                *                      By:                 *
    -----------------------------------      -----------------------------------
    Christopher J. Spray,                    Hans Bosman,
    General Partner                          Managing Director


                   *
- ---------------------------------------
Christopher J. Spray

                   *
- ---------------------------------------
Barry Fidelman

                   *
- ---------------------------------------
Jean-Francois Formela

*   The undersigned attorney-in-fact, by signing her name below, does hereby
    sign this statement on behalf of the above indicated filers pursuant to
    Powers of Attorney filed hereto as Exhibit 2.
                                       ---------

     /s/ Jeanne Larkin Henry
     -----------------------
     Jeanne Larkin Henry
     Attorney-in-fact


Page 14 of 19



                                                                       Exhibit 2
                                                                       ---------

                                POWER OF ATTORNEY


         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints each and any of Christopher J.
Spray and Jeanne Larkin Henry his true and lawful attorney-in-fact and agent,
with full power of substitution and resubstitution, for him and in his name,
place and stead, in any and all capacities (until revoked in writing) to sign
any and all instruments, certificates and documents required to be executed on
behalf of himself individually or on behalf of each or any of Atlas Venture
Fund, L.P., Atlas Venture Associates, L.P., Atlas Venture Partners III, B.V.,
Atlas Venture Fund II, L.P., Atlas Venture Associates II, L.P., Atlas Venture
Europe Fund B.V., Atlas InvesteringsGroep N.V., and Atlas Venture Beheer II B.V.
pursuant to sections 13 and 16 of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), and any and all regulations promulgated
thereunder, and to file the same, with all exhibits thereto, and any other
documents in connection therewith, with the Securities and Exchange Commission,
and with any other entity when and if such is mandated by the Exchange Act or by
the By-laws of the National Association of Securities Dealers, granting unto
said attorney-in-fact and agent full power and authority to do and perform each
and every act and thing requisite and necessary fully to all intents and
purposes as he might or could do in person thereby ratifying and confirming all
that said attorney-in-fact and agent, or his substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.



                  [REMAINDER OF PAGE LEFT BLANK INTENTIONALLY]

                      [SIGNATURE PAGE FOLLOWS IMMEDIATELY]

Page 15 of 19



         IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
31st day of January, 1997.

                                             /s/ Christopher J. Spray
                                             -----------------------------------
                                             Christopher J. Spray


Commonwealth of Massachusetts)
                             ) ss:
County of Suffolk            )

         On this 31st day of January, 1997, before me personally came
Christopher J. Spray, known to me to be the person described and who executed
the foregoing instrument that he acknowledged that he executed the same.


[Notary Seal]                                /s/ Elizabeth  A. LeBlanc
                                             -----------------------------------
                                             Notary Public

                                             My commission expires: July 3, 1998

Page 16 of 19



      IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
31st day of January, 1997.




                                        /s/ Barry Fidelman
                                        -------------------------------------
                                        Barry Fidelman


Commonwealth of Massachusetts)
                             ) ss:
County of Suffolk            )

      On this 31st day of January, 1997, before me personally came Barry
Fidelman, known to me to be the person described and who executed the foregoing
instrument that he acknowledged that he executed the same.


[Notary Seal]                           /s/ Elizabeth  A. LeBlanc
                                        -------------------------------------
                                        Notary Public

                                        My commission expires: July 3, 1998

Page 17 0f 19



      IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
31st day of January, 1997.

                                        /s/ Jean-Francois Formela
                                        -------------------------------------
                                        Jean-Francois Formela


Commonwealth of Massachusetts)
                             ) ss:
County of Suffolk            )

      On this 31st day of January, 1997, before me personally came Jean-
Francois Formela, known to me to be the person described and who executed the
foregoing instrument that he acknowledged that he executed the same.

[Notary Seal]                           /s/ Elizabeth  A. LeBlanc
                                        -------------------------------------
                                        Notary Public

                                        My commission expires: July 3, 1998

Page 18 of 19



      IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 7th
day of February, 2000.




                                        /s/ Hans Bosman
                                        -------------------------------------
                                        Hans Bosman


Commonwealth of Massachusetts)
                             ) ss:
County of Suffolk            )

      On this 7th day of February, 2000, before me personally came Hans
Bosman, known to me to be the person described and who executed the foregoing
instrument that he acknowledged that he executed the same.

[Notary Seal]                           /s/ Ann M. Grummitt
                                        -------------------------------------
                                        Notary Public

                                        My commission expires: November 6, 2003

Page 19 of 19