UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  ____________

                                 SCHEDULE 13G/A

                                (Amendment No. 1)

                    Under the Securities Exchange Act of 1934

                                 Exelixis, Inc.
- --------------------------------------------------------------------------------
                                (Name of issuer)

                     Common Stock, par value $.001 per share
- --------------------------------------------------------------------------------
                         (Title of class of securities)

                                    30161Q104
- --------------------------------------------------------------------------------
                                 (CUSIP number)

                                December 31, 2001
- --------------------------------------------------------------------------------
             (Date of Event which requires filing of this Statement)

                 Check the appropriate box to designate the rule
                   pursuant to which this schedule is filed:

                               /_/ Rule 13d-1 (b)
                               /X/ Rule 13d-1 (c)
                               /_/ Rule 13d-1 (d)



- ---------------------                                      ---------------------
CUSIP No. 30161Q104                   13G                     Page 2 of 10 Pages
- ---------------------                                      ---------------------



- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank AG
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) /_/
                                                                       (b) /_/
- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY OWNED BY               SHARED VOTING POWER
                             6      2,391,000
                             ------ --------------------------------------------
EACH REPORTING                      SOLE DISPOSITIVE POWER
                             7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,391,000
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,391,000*
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                     /_/
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         4.8%**
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
- -------- -----------------------------------------------------------------------


*    Included in this  figure are the  securities  reported  by  Deutsche  Asset
     Management  Europe  GmbH  (f/k/a  Deutsche  Fonds  Holding  GmbH)  and  DWS
     Investment GmbH on the following cover pages.

**   Included in this  percentage is the  percentage  of securities  reported by
     Deutsche Asset  Management  Europe GmbH (f/k/a Deutsche Fonds Holding GmbH)
     and DWS Investment GmbH on the following cover pages.


                                      -2-



- ---------------------                                      ---------------------
CUSIP No. 30161Q104                   13G                     Page 3 of 10 Pages
- ---------------------                                      ---------------------


- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Asset Management Europe GmbH
         (f/k/a Deutsche Fonds Holding GmbH)
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) /_/
                                                                       (b) /_/
- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,391,000
                             ------ --------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,391,000
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,391,000*
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                     /_/
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         4.8%**
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC
- -------- -----------------------------------------------------------------------


*    Included in this figure are the securities  reported by DWS Investment GmbH
     on the following cover page.

**   Included in this percentage is the percentage of securities reported by DWS
     Investment GmbH on the following cover page.


                                      -3-



- ---------------------                                      ---------------------
CUSIP No. 30161Q104                   13G                     Page 4 of 10 Pages
- ---------------------                                      ---------------------


- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         DWS Investment GmbH
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) /_/
                                                                       (b) /_/
- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,266,000
                             ------ --------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,266,000
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,266,000
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                     /_/
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         4.6%
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC
- -------- -----------------------------------------------------------------------


                                      -4-




Item 1(a).        Name of Issuer:

                  Exelixis, Inc. (the "Issuer")

Item 1(b).        Address of Issuer's Principal Executive Offices:

                  The address of the Issuer's principal executive offices is 170
Harbor Way, P.O. Box 511, South San Francisco, CA 94083.

Item 2(a).        Name of Person Filing:

                  This  statement  is  filed  on  behalf  of  Deutsche  Bank  AG
("DBAG"),  Deutsche Asset  Management  Europe GmbH (f/k/a Deutsche Fonds Holding
GmbH) ("DWS Group") and DWS Investment  GmbH ("DWS" and,  together with DBAG and
DWS Group, the "Reporting Persons"). This Schedule 13G/A is being filed pursuant
to Rule 13d-2(b).

Item 2(b).        Address of Principal Business Office or, if none, Residence:

                  The principal  place of business of DBAG is  Taunusanlage  12,
D-60325, Frankfurt am Main, Federal Republic of Germany.

                  The   principal   place   of   business   of  DWS   Group   is
Feldbergstrasse 22, 60323 Frankfurt, Federal Republic of Germany.

                  The  principal  place  of  business  of  DWS  is  Gruneburgweg
113-115, 60612 Frankfurt, Federal Republic of Germany.

Item 2(c).        Citizenship:

                  The  citizenship  of the Reporting  Person is set forth on the
cover page.

Item 2(d).        Title of Class of Securities:

                  The title of the  securities  is  Common  Stock  (the  "Common
Stock").

Item 2(e).        CUSIP Number:

                  The CUSIP number of the Common Stock is set forth on the cover
page.

Item 3.           If this  statement  is filed  pursuant to Rules  13d-1(b),  or
                  13d-2(b) or (c), check whether the person filing is a:

                  (a)  /_/ Broker or dealer  registered  under section 15 of the
                       Act;

                  (b)  /_/ Bank as defined in section 3(a)(6) of the Act;

                  (c)  /_/ Insurance  Company as defined in section  3(a)(19) of
                       the Act;

                  (d)  /_/ Investment  Company registered under section 8 of the
                       Investment Company Act of 1940;


                                      -5-





                  (e)  /_/ An investment  adviser in accordance  with Rule 13d-1
                       (b)(1)(ii)(E);

                  (f)  /_/ An  employee  benefit  plan,  or  endowment  fund  in
                       accordance with Rule 13d-1 (b)(1)(ii)(F);

                  (g)  /_/  A  parent  holding  company  or  control  person  in
                       accordance with Rule 13d-1 (b)(1)(ii)(G);

                  (h)  /_/ A savings  association  as defined in section 3(b) of
                       the Federal Deposit Insurance Act;

                  (i)  /_/ A church plan that is excluded from the definition of
                       an  investment  company  under  section  3(c)(14)  of the
                       Investment Company Act of 1940;

                  (j)  /_/ Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

                  If this statement is filed  pursuant to Rule  13d-1(c),  check
this box. /X/

Item 4.           Ownership.

                  (a) Amount beneficially owned:

                      Each  of  the  Reporting  Persons  owns  the amount of the
                  Common Stock as set forth on the applicable cover page.

                  (b) Percent of class:

                      Each of the  Reporting  Persons  owns  the  percentage  of
                  the Common Stock as set forth on the applicable cover page.

                  (c) Number of shares as to which such person has:

                      (i) sole power to vote or to direct the vote:

                          The  Reporting  Person  has the sole  power to vote or
                      direct  the vote of the  Common  Stock as set forth on the
                      cover page.

                      (ii) shared power to vote or to direct the vote:

                          Each of  the  Reporting  Persons has  the shared power
                      to vote or direct  the vote  of the  Common  Stock  as set
                      forth on the applicable cover page.

                      (iii) sole  power to dispose or to direct the  disposition
                            of:

                          Each of  the Reporting  Persons  has the sole power to
                      dispose or direct the disposition  of  the Common Stock as
                      set forth on the applicable cover page.


                                      -6-





                      (iv) shared power to dispose or to direct the  disposition
                           of:

                          Each of the  Reporting  Persons  has  the shared power
                      to dispose  or  direct the disposition of the Common Stock
                      as set forth on the applicable cover page.

Item 5.           Ownership of Five Percent or Less of a Class.

                  If this statement is being filed to report the fact that as of
the date hereof the reporting persons have ceased to be the beneficial owners of
more than five percent of the class of securities check the following [x].

Item 6.           Ownership  of  More  than  Five  Percent  on Behalf of Another
                  Person.

                  Not applicable.

Item 7.           Identification  and  Classification  of  the  Subsidiary Which
                  Acquired the Security Being Reported on by the  Parent Holding
                  Company.

                  The following is a subsidiary  of the Reporting  Persons which
holds Common Stock  included in the figures on the cover pages:  DWS  Investment
S.A. Luxemburg.

Item 8.           Identification and Classification of Members of the Group.

                  Not applicable.

Item 9.           Notice of Dissolution of Group.

                  Not applicable.

Item 10.          Certification.

                  By signing  below I certify  that, to the best of my knowledge
and belief, the securities  referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing  the control of
the  issuer  of the  securities  and  were  not  acquired  and are  not  held in
connection  with or as a participant in any  transaction  having that purpose or
effect.


                                      -7-



                                    SIGNATURE

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  February 12, 2002



                                         DEUTSCHE BANK AG



                                         By:  /s/ Jeffrey A. Ruiz
                                             Name:     Jeffrey A. Ruiz
                                             Title:    Vice President



                                         By: /s/ Margaret M. Adams
                                             Name:     Margaret M. Adams
                                             Title:    Director


                                      -8-




                                                                       EXHIBIT 1

                Consent of Deutsche Asset Management Europe GmbH
                      (f/k/a Deutsche Fonds Holding GmbH)


     The undersigned agrees that the Schedule 13G/A executed by Deutsche Bank AG
to which this statement is attached as an exhibit is filed on behalf of Deutsche
Bank AG,  Deutsche Asset  Management  Europe GmbH (f/k/a  Deutsche Fonds Holding
GmbH) and DWS  Investment  GmbH pursuant to Rule  13d-1(k)(1)  of the Securities
Exchange Act of 1934.

Dated:  February 12, 2002



                                 DEUTSCHE ASSET MANAGEMENT EUROPE GMBH
                                  (F/K/A DEUTSCHE FONDS HOLDING GMBH)



                                 By:   /s/ Dr. Dieter Eisele
                                      Name: Dr. Dieter Eisele
                                      Title: Global Head of Compliance



                                 By:   /s/ Michaela Bundschuh
                                      Name: Michaela Bundschuh
                                      Title: Head Position Monitoring



                                                                       EXHIBIT 2

                         Consent of DWS Investment GmbH


     The undersigned agrees that the Schedule 13G/A executed by Deutsche Bank AG
to which this statement is attached as an exhibit is filed on behalf of Deutsche
Bank AG,  Deutsche Asset  Management  Europe GmbH (f/k/a  Deutsche Fonds Holding
GmbH) and DWS  Investment  GmbH pursuant to Rule  13d-1(k)(1)  of the Securities
Exchange Act of 1934.

Dated:  February 12, 2002



                                 DWS INVESTMENT GMBH



                                 By:   /s/ Dr. Dieter Eisele
                                      Name: Dr. Dieter Eisele
                                      Title: Global Head of Compliance



                                 By:   /s/ Michaela Bundschuh
                                      Name: Michaela Bundschuh
                                      Title: Head Position Monitoring