<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:09cb6ac2-199a-4658-92e7-be7edaf58e8a,g:cfcb6897-bae4-462e-852c-f27a52e7413c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.exelixis.com/role/CoverPage" xlink:type="simple" xlink:href="exel-20240806.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.exelixis.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_8fec3117-ee31-4305-a9bd-d7b6d8c21215" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_AmendmentFlag_8fec3117-ee31-4305-a9bd-d7b6d8c21215" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_6e08f420-5298-450c-a8ed-e2b8bc15e2c7" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_DocumentPeriodEndDate_6e08f420-5298-450c-a8ed-e2b8bc15e2c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_ba8bbdc1-dd9a-41c0-aa28-2c22e4f686fe" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityRegistrantName_ba8bbdc1-dd9a-41c0-aa28-2c22e4f686fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_16600f50-4ae8-49c5-b0f7-1b56df6e6789" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityCentralIndexKey_16600f50-4ae8-49c5-b0f7-1b56df6e6789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_21e5a898-0e93-4919-9280-67c1f7fa5ded" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityEmergingGrowthCompany_21e5a898-0e93-4919-9280-67c1f7fa5ded" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_bda8ffb3-7d47-40ac-9d58-aef0b50fe742" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_Security12bTitle_bda8ffb3-7d47-40ac-9d58-aef0b50fe742" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_63fb4b47-6168-4d74-ba64-cdd9742caf97" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_TradingSymbol_63fb4b47-6168-4d74-ba64-cdd9742caf97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_a6813a63-592f-4a87-b3f1-eab184bfe828" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_SecurityExchangeName_a6813a63-592f-4a87-b3f1-eab184bfe828" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_f4fddf9e-809c-4793-928c-97ddf429b90e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityFileNumber_f4fddf9e-809c-4793-928c-97ddf429b90e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_03157333-57ff-4f51-b226-ddf3ad5da717" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityIncorporationStateCountryCode_03157333-57ff-4f51-b226-ddf3ad5da717" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_66e79adc-55a2-4f66-9acd-8fd09e5df791" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityTaxIdentificationNumber_66e79adc-55a2-4f66-9acd-8fd09e5df791" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_86c81188-1ad2-4d31-b0a3-7e0b7feed61f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityAddressAddressLine1_86c81188-1ad2-4d31-b0a3-7e0b7feed61f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a5877dbd-fee2-4ae8-9097-de266c4126c5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityAddressCityOrTown_a5877dbd-fee2-4ae8-9097-de266c4126c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_89885ce5-ec06-4db2-ac4d-49e621b43674" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityAddressStateOrProvince_89885ce5-ec06-4db2-ac4d-49e621b43674" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_6b48af38-19de-4a45-abc2-6def18072f4e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_EntityAddressPostalZipCode_6b48af38-19de-4a45-abc2-6def18072f4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_9a074cc3-cae4-4bc6-a3cb-e47cdd65201b" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_CityAreaCode_9a074cc3-cae4-4bc6-a3cb-e47cdd65201b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_b10369dd-fd4d-44e6-b345-d5031fc5a1ca" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_LocalPhoneNumber_b10369dd-fd4d-44e6-b345-d5031fc5a1ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_59d3e409-ca9b-40b9-87af-aaf3903d03da" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_WrittenCommunications_59d3e409-ca9b-40b9-87af-aaf3903d03da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_34a3f0eb-87b6-41b3-a70c-84f4998aec83" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_SolicitingMaterial_34a3f0eb-87b6-41b3-a70c-84f4998aec83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_de20ed90-b251-4682-ab04-3972320051d5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_PreCommencementTenderOffer_de20ed90-b251-4682-ab04-3972320051d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_5ae94726-dcc6-4077-9e2f-2976565b5264" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_5ae94726-dcc6-4077-9e2f-2976565b5264" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_865a4819-2247-4096-8ca3-fbcefa3e1e08" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f959386b-e138-4233-845a-cb46cfd6350d" xlink:to="loc_dei_DocumentType_865a4819-2247-4096-8ca3-fbcefa3e1e08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
