Press Release

Exelixis Announces January 12 Webcast of Presentation at the 28th
Annual J.P. Morgan Healthcare Conference

December 9, 2009
SOUTH SAN FRANCISCO, Calif., Dec 09, 2009 (BUSINESS WIRE) -- Exelixis, Inc. (NASDAQ:EXEL) announced today that George A. Scangos, PhD, the company's president and chief executive officer, will present at the 28th Annual J.P. Morgan Healthcare Conference at 11:00 a.m. EST / 8:00 a.m. PST on Tuesday January 12, 2010 in San Francisco. Dr. Scangos will discuss the company's corporate strategy, financial outlook and development pipeline.

The event will be webcast and may be accessed in the Event Calendar page under Investors at http://www.exelixis.com.

About Exelixis

Exelixis, Inc. is a development-stage biotechnology company dedicated to the discovery and development of novel small molecule therapeutics for the treatment of cancer and other serious diseases. The company is leveraging its fully integrated drug discovery platform to fuel the growth of its development pipeline, which is primarily focused on cancer. Currently, Exelixis' broad product pipeline includes investigational compounds in phase 3, phase 2, and phase 1 clinical development. Exelixis has established strategic corporate alliances with major pharmaceutical and biotechnology companies, including Bristol-Myers Squibb, sanofi-aventis, GlaxoSmithKline, Genentech, Boehringer Ingelheim, Pfizer Inc., and Daiichi-Sankyo. For more information, please visit the company's web site at http://www.exelixis.com.

Exelixis and the Exelixis logo are registered U.S. trademarks.

SOURCE: Exelixis, Inc.

Exelixis, Inc.
Charles Butler, 650-837-7277
Vice President,
Investor Relations
and Corporate Communications
cbutler@exelixis.com
DeDe Sheel, 650-837-8231
Associate Director,
Investor Relations
dsheel@exelixis.com