Prospectus  Supplement  No.  1
                                                               Filed Pursuant to
                                                        Rule 424 (b) (3) and (c)
                                                              File No. 333-62094

                                 EXELIXIS, INC.
                                2,270,522 SHARES
                                  COMMON STOCK

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     This prospectus supplement supplements the prospectus, dated June 12, 2001,
of  Exelixis,  Inc.  relating  to  the  public  offering,  which  is  not  being
underwritten,  and sale of up to 2,270,522 shares of our common stock by selling
stockholders  of  Exelixis  (or  by  donees,  pledgees,  transferees  and  other
successors  in  interest that receive such shares as a gift, pledge, partnership
distribution  or  other non-sale transfer) who recived such shares in connection
with  our  acquisition  of  Artemis  Pharmaceuticals  GmbH.  This  prospectus
supplement  should  be  read  in  conjunction  with  the  prospectus,  and  this
prospectus supplement is qualified by reference to the prospectus, except to the
extent  that  the  information provided by this prospectus supplement supersedes
the  information  contained  in  the  prospectus.

SEE  "RISK  FACTORS" BEGINNING ON PAGE 4 OF THE PROSPECTUS TO READ ABOUT FACTORS
YOU  SHOULD  CONSIDER  BEFORE  BUYING  OUR  COMMON  STOCK.


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     The  shares offered or sold under this prospectus have not been approved by
the  Securities  and  Exchange Commission or any state securities commission nor
have  any  of these organizations determined that this prospectus is accurate or
complete.  Any  representation  to  the  contrary  is  a  criminal  offense.


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            The date of this prospectus supplement is June 26, 2002.


The table and related notes appearing in the prospectus, dated June 12, 2001, under the heading "Selling Stockholders" is superseded by the following table and related notes as of June 26, 2002: Selling Stockholders Shares Beneficially Shares Beneficially Owned Prior to the Number of Owned After the Offering Shares Being Offering (1) --------------------- -------------------- Name Number Percent Offered Number Percent - -------------------------------------------------------------- --------- ---------- ----------------- --------- ---------- 3i Group Investments Limited Partnership . . . . . . . . . . . 387,706 * 387,706 0 * Advent Partners Limited Partnership(2) . . . . . . . . . . . . 68,078 * 4,064 64,014 * Advent Performance Materials Limited Partnership(2) . . . . . . . . . . . . . . . . . . . . . . . . 296,592 * 9,347 287,245 * Adwest Limited Partnership(2). . . . . . . . . . . . . . . . . 169,831 * 5,690 164,141 * Rovent II Limited Partnership(2) . . . . . . . . . . . . . . . 1,185,153 2.4% 36,170 1,148,983 2.3% Atlas Venture Europe Fund B.V.(3). . . . . . . . . . . . . . . 1,263,450 2.6 26,010 1,237,440 2.5 Atlas Venture Fund II, L.P.(3) . . . . . . . . . . . . . . . . 2,641,418 5.4 160,122 2,481,296 5.1 Atlas Venture Germany B.V.(3). . . . . . . . . . . . . . . . . 54,051 * 54,051 0 * Guido Arens. . . . . . . . . . . . . . . . . . . . . . . . . . 1,741 * 1,741 0 * Martina Beck . . . . . . . . . . . . . . . . . . . . . . . . . 120 * 120 0 * Petra Beeckmann. . . . . . . . . . . . . . . . . . . . . . . . 1,703 * 1,703 0 * Marion Bernzen . . . . . . . . . . . . . . . . . . . . . . . . 527 * 527 0 * Gerd Beyer . . . . . . . . . . . . . . . . . . . . . . . . . . 2,044 * 2,044 0 * Biotechvest Limited Partnership. . . . . . . . . . . . . . . . 2,032 * 2,032 0 * Commerz Beteiligungsgesellschaft GmbH. . . . . . . . . . . . . 38,608 * 38,608 0 * Maria da Silva . . . . . . . . . . . . . . . . . . . . . . . . 96 * 96 0 * Alf Domeyer. . . . . . . . . . . . . . . . . . . . . . . . . . 1,703 * 1,703 0 * Peter Erken. . . . . . . . . . . . . . . . . . . . . . . . . . 45 * 45 0 * Nicole Faust . . . . . . . . . . . . . . . . . . . . . . . . . 5,272 * 5,272 0 * Susanne Felder . . . . . . . . . . . . . . . . . . . . . . . . 2,413 * 2,413 0 * Manuela Flad . . . . . . . . . . . . . . . . . . . . . . . . . 193 * 193 0 * Berthold Gierke. . . . . . . . . . . . . . . . . . . . . . . . 460 * 460 0 * Nicole Glesmann. . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Global Life Science Holding V GmbH . . . . . . . . . . . . . . 100,787 * 100,787 0 * Monique Goerl. . . . . . . . . . . . . . . . . . . . . . . . . 209 * 209 0 * Iris Gorcke. . . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Sandra Graf. . . . . . . . . . . . . . . . . . . . . . . . . . 173 * 173 0 * Ursula Hagner. . . . . . . . . . . . . . . . . . . . . . . . . 133 * 133 0 * Monika Hahn-Wansel . . . . . . . . . . . . . . . . . . . . . . 1,741 * 1,741 0 * Cornelia Heimann . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Thomas Hennek. . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Elisabeth Hennen . . . . . . . . . . . . . . . . . . . . . . . 240 * 240 0 * Biomedicine L.P.(4). . . . . . . . . . . . . . . . . . . . . . 399,085 * 399,085 0 * Rudi Jaenisch. . . . . . . . . . . . . . . . . . . . . . . . . 3,548 * 3,548 0 * Michelle Johnson . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Christian Kaps . . . . . . . . . . . . . . . . . . . . . . . . 1,135 * 1,135 0 * Gunter Kauselmann. . . . . . . . . . . . . . . . . . . . . . . 3,990 * 3,990 0 * Heinrich Kehlbeck. . . . . . . . . . . . . . . . . . . . . . . 3,066 * 3,066 0 * Heidrun Kern . . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Mike Kierdorf. . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Anja Kirchner. . . . . . . . . . . . . . . . . . . . . . . . . 201 * 201 0 * Thomas Koblizek Dr . . . . . . . . . . . . . . . . . . . . . . 1,703 * 1,703 0 * Dagmar Kluth . . . . . . . . . . . . . . . . . . . . . . . . . 2,163 * 2,163 0 * Nicole Krafzik . . . . . . . . . . . . . . . . . . . . . . . . 870 * 870 0 * Barbara Kraus. . . . . . . . . . . . . . . . . . . . . . . . . 3,390 * 3,390 0 * Ralf Kuhn. . . . . . . . . . . . . . . . . . . . . . . . . . . 18,656 * 18,656 0 * Birgit Kuter-Luks. . . . . . . . . . . . . . . . . . . . . . . 475 * 475 0 * Janice Labedzki. . . . . . . . . . . . . . . . . . . . . . . . 144 * 144 0 * Ulrike Langheinrich. . . . . . . . . . . . . . . . . . . . . . 5,272 * 5,272 0 * Carsten Loeschke . . . . . . . . . . . . . . . . . . . . . . . 45 * 45 0 * Sabine Maurer. . . . . . . . . . . . . . . . . . . . . . . . . 66 * 66 0 * Dagmar Megerle . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * MILOS Vermogensverwaltungs GmbH. . . . . . . . . . . . . . . . 93,066 * 93,066 0 * Heiderose Neu. . . . . . . . . . . . . . . . . . . . . . . . . 235 * 235 0 * Renate Nordin. . . . . . . . . . . . . . . . . . . . . . . . . 120 * 120 0 * Christiane Nusslein-Volhand. . . . . . . . . . . . . . . . . . 131,674 * 131,674 0 * Jorg Odenthal. . . . . . . . . . . . . . . . . . . . . . . . . 11,194 * 11,194 0 * Oxford Bioscience Partners (Adjunct) II Limited Partnership(5) 12,599 * 12,599 0 * Oxford Bioscience Partners (Bermuda) II Limited Partnership(5) 33,325 * 33,325 0 * Oxford Bioscience Partners (GS-Adjunct) II Limited Partnership(5) . . . . . . . . . . . . . . . . . . . . 44,297 * 44,297 0 * Oxford Bioscience Partners II Limited Partnership(5) . . . . . . . . . . . . . . . . . . . . . . . . 45,517 * 45,517 0 * Niketan Pandit . . . . . . . . . . . . . . . . . . . . . . . . 227 * 227 0 * Stelios Papadopoulos(6). . . . . . . . . . . . . . . . . . . . 482,277 * 4,064 478,213 * Margot Paul. . . . . . . . . . . . . . . . . . . . . . . . . . 240 * 240 0 * Marion Pezzuti . . . . . . . . . . . . . . . . . . . . . . . . 120 * 120 0 * Max-Planck-Gesellschaft. . . . . . . . . . . . . . . . . . . . 50,800 * 50,800 0 * Yvonne Postma. . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Christiane Priebnitz . . . . . . . . . . . . . . . . . . . . . 416 * 416 0 * Klaus Rajewsky . . . . . . . . . . . . . . . . . . . . . . . . 131,674 * 131,674 0 * Karlheinz Rein . . . . . . . . . . . . . . . . . . . . . . . . 1,703 * 1,703 0 * Anja Rode. . . . . . . . . . . . . . . . . . . . . . . . . . . 713 * 713 0 * Paul Rounding. . . . . . . . . . . . . . . . . . . . . . . . . 10,545 * 10,545 0 * Andrea Sabiwalsky. . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * Caroline Samuel. . . . . . . . . . . . . . . . . . . . . . . . 1,203 * 1,203 0 * Ieda Santana-Stamm . . . . . . . . . . . . . . . . . . . . . . 45 * 45 0 * Jochen Scheel. . . . . . . . . . . . . . . . . . . . . . . . . 11,194 * 11,194 0 * Nico Scheer. . . . . . . . . . . . . . . . . . . . . . . . . . 1,703 * 1,703 0 * Lothar Schleithoff . . . . . . . . . . . . . . . . . . . . . . 2,271 * 2,271 0 * Michael Schoor . . . . . . . . . . . . . . . . . . . . . . . . 3,613 * 3,613 0 * Stefan Schulte-Merker. . . . . . . . . . . . . . . . . . . . . 21,144 * 21,144 0 * Daniela Schulz . . . . . . . . . . . . . . . . . . . . . . . . 45 * 45 0 * Frieder Schwenk. . . . . . . . . . . . . . . . . . . . . . . . 12,437 * 12,437 0 * Jost Seibler . . . . . . . . . . . . . . . . . . . . . . . . . 1,906 * 1,906 0 * Stefan Spieb . . . . . . . . . . . . . . . . . . . . . . . . . 1,135 * 1,135 0 * Peter Stadler(7) . . . . . . . . . . . . . . . . . . . . . . . 427,917 * 197,917 230,000 * Miriam Stahl . . . . . . . . . . . . . . . . . . . . . . . . . 210 * 210 0 * Gordon Stott . . . . . . . . . . . . . . . . . . . . . . . . . 2,007 * 2,007 0 * Jens Tampe . . . . . . . . . . . . . . . . . . . . . . . . . . 2,271 * 2,271 0 * Tbg Technologie-Beteiligungs . . . . . . . . . . . . . . . . . 116,230 * 116,230 0 * Danja Thiel. . . . . . . . . . . . . . . . . . . . . . . . . . 63 * 63 0 * Hartmut Tintrup. . . . . . . . . . . . . . . . . . . . . . . . 3,893 * 3,893 0 * Ute Tinsz. . . . . . . . . . . . . . . . . . . . . . . . . . . 100 * 100 0 * Torsten Trowe. . . . . . . . . . . . . . . . . . . . . . . . . 12,437 * 12,437 0 * Gabriele Vacun . . . . . . . . . . . . . . . . . . . . . . . . 416 * 416 0 * Thomas Wagner. . . . . . . . . . . . . . . . . . . . . . . . . 6,748 * 6,748 0 * Brigitte Walderich . . . . . . . . . . . . . . . . . . . . . . 5,542 * 5,542 0 * Andreas Walker . . . . . . . . . . . . . . . . . . . . . . . . 56 * 56 0 * Michael Walker . . . . . . . . . . . . . . . . . . . . . . . . 452 * 452 0 * Catrin Weiler. . . . . . . . . . . . . . . . . . . . . . . . . 870 * 870 0 * Heike Wessendorf . . . . . . . . . . . . . . . . . . . . . . . 567 * 567 0 * Branko Zevnik. . . . . . . . . . . . . . . . . . . . . . . . . 3,066 * 3,066 0 * Sandra Zymny . . . . . . . . . . . . . . . . . . . . . . . . . 113 * 113 0 * ----------------- Total . . . . . . . . . . . . . . . . . . . . . . . . . . . 2,270,522 ----------------- _______________________ (1) Assumes the sale of all shares offered hereby. (2) This fund is managed by Advent International Corporation ("Advent"), which exercises sole voting and investment power with respect to all shares held by this fund. Advent International Investors II, L.P., which is another fund affiliated with Advent, holds 3,614 shares of Exelixis common stock but is not a selling stockholder. All of the funds affiliated with Advent own 3.5% prior to the offering and 3.4% after the offering. Jason S. Fisherman, M.D. is a vice president of Advent and has been a director of Exelixis since March 1996. Dr. Fisherman disclaims beneficial ownership of these shares except for 17,493 shares that are indirectly beneficially owned by Dr. Fisherman. (3) This fund is managed by Atlas Venture ("Atlas"), which consists of a group of funds under common control. All of the funds affiliated with Atlas own 8.1% prior to the offering and 7.6% after the offering. Jean-Francois Formela, M.D. is a general partner of Atlas and has been a director of Exelixis since September 1995. No general partner of Atlas is deemed to have voting and investment power with respect to such shares, and Dr. Formela disclaims beneficial ownership of these shares. (4) Jurgen Drews, M.D. has been a director of Exelixis since July 1998. Dr. Drews was Chairman of the Board of Biomedicine L.P. (formerly International BM Biomedicine Holdings AG), from October 1997 until January 2001. (5) Edmund Olivier de Vezin is a general partner of Oxford Bioscience Partners and was a director of Exelixis from July 1997 until May 2001. Mr. Olivier disclaims beneficial ownership of these shares except to the extent of his proportionate partnership interest in these shares. (6) Dr. Papadopoulos has been a director of Exelixis since December 1994 and Chairman of the Board since January 1998. Dr. Papadopoulos' stock holdings include 10,000 shares held by Foundation Sante, of which Dr. Papadopoulos is co-trustee, and 30,000 shares that Dr. Papadopoulos has the right to acquire pursuant to an option exercisable within 60 days of May 14, 2001, 17,605 of which would be subject to repurchase by Exelixis. (7) Dr. Stadler has been a director of Exelixis since April 1998. Dr. Stadler has been Managing Director of Artemis Pharmaceuticals GmbH since May 2001. Dr. Stadler's stock holdings consist of 167,500 shares that Dr. Stadler has the right to acquire pursuant to an option exercisable within 60 days of May 14, 2001, 41,042 of which would be subject to repurchase by Exelixis. We may from time to time supplement or amend the prospectus to reflect the required information concerning a transferee, pledgee, donee or successor to the Selling Stockholders named in the prospectus.